PINK1-Mediated Mitochondrial Activity Confers Olaparib Resistance in Prostate Cancer Cells.

Autor:	Schaaf ZA; Department of Urologic Surgery, University of California Davis, Davis, California., Ning S; Department of Urologic Surgery, University of California Davis, Davis, California., Leslie AR; Department of Urologic Surgery, University of California Davis, Davis, California., Sharifi M; Department of Urologic Surgery, University of California Davis, Davis, California., Gao RY; Division of Hematology and Oncology, University of California Davis, Davis, California., Maine JP; Department of Urologic Surgery, University of California Davis, Davis, California., Lou W; Department of Urologic Surgery, University of California Davis, Davis, California., Lombard AP; Department of Urologic Surgery, University of California Davis, Davis, California.; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California.; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California., Liu C; Department of Urologic Surgery, University of California Davis, Davis, California.; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California., Yu AM; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California.; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California., Mitsiades N; Division of Hematology and Oncology, University of California Davis, Davis, California.; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California., Gao AC; Department of Urologic Surgery, University of California Davis, Davis, California.; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California.; VA Northern California Health Care System, Sacramento, California.
Jazyk:	angličtina
Zdroj:	Cancer research communications [Cancer Res Commun] 2024 Nov 01; Vol. 4 (11), pp. 2976-2985.
DOI:	10.1158/2767-9764.CRC-24-0339
Abstrakt:	Significance: Olaparib, a PARP inhibitor, is effective against various cancers, including prostate cancer. However, resistance to olaparib poses a significant challenge. This study uncovers that mitochondrial alterations and PINK1 gene overexpression contribute to this resistance in prostate cancer cells. Enhanced mitochondrial functionality and increased PINK1 expression in olaparib-resistant cells underscore the importance of targeting mitochondrial dynamics and PINK1 to develop more effective treatments for overcoming olaparib resistance in prostate cancer. (©2024 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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