Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey.

Autor:	Sá ACMGN; Universidade Federal de Minas Gerais, Nursing School, Graduate Program in Nursing - Belo Horizonte (MG), Brazil., Silva AGD; Universidade Federal de Minas Gerais, Nursing School, Department of Maternal-Child and Public Health Nursing, Graduate Program in Nursing - Belo Horizonte (MG), Brazil., Gomes CS; Universidade Federal de Minas Gerais, Medical School, Graduate Program in Public Health - Belo Horizonte (MG), Brazil., Sá ATN; Universidade Federal de Minas Gerais, Medical School, Graduate Program in Sciences Applied to Adult Health, Hospital das Clínicas, and Department of Occupational Health Assistance - Belo Horizonte (MG), Brazil.; Faculdade de Ciências Médicas de Minas Gerais, Medical Clinic Department - Belo Horizonte (MG), Brazil., Malta DC; Universidade Federal de Minas Gerais, Nursing School, Department of Maternal-Child and Public Health Nursing - Belo Horizonte (MG), Brasil.
Jazyk:	English; Portuguese
Zdroj:	Revista brasileira de epidemiologia = Brazilian journal of epidemiology [Rev Bras Epidemiol] 2023 Apr 21; Vol. 26Suppl 1 (Suppl 1), pp. e230003. Date of Electronic Publication: 2023 Apr 21 (Print Publication: 2023).
DOI:	10.1590/1980-549720230003.supl.1
Abstrakt:	Objective: To compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, based on the National Health Survey, 2014-2015, composed of 8,952 individuals. The sample of patients with SCT was composed of 234 adults. The RIs of adults with and without SCT were compared in the study "Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey", by Rosenfeld et al. (2019). The parametric method and the Student's t test were used for comparison (p≤0.05). Results: There were statistically significant differences between RIs of adults with and without SCT as far as sex is concerned for hemoglobin, MCV, MCH, MCHC, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, MCH, MCHC, mean platelet volume and RDW in women; Between 18 to 59 years, for MCH, MCV, MCHC, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years old on, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown people for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, MCH, MCHC, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and further research to support the proper management of this condition in Brazil.
Databáze:	MEDLINE
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