20-HETE, Blood Pressure, and Vascular Stiffness in Young Adults.

Autor:	Barden AE; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia (A.E.B., S.S., L.J.B., T.A.M.)., Shinde S; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia (A.E.B., S.S., L.J.B., T.A.M.)., Beilin LJ; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia (A.E.B., S.S., L.J.B., T.A.M.)., Phillips M; Harry Perkins Institute for Medical Research, Murdoch, Western Australia, Australia (M.P.).; Royal Perth Hospital Medical Research Foundation, Western Australia, Australia (M.P.)., Adler B; Envision Medical Imaging Perth, Western Australia, Australia (B.A.)., Mori TA; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia (A.E.B., S.S., L.J.B., T.A.M.).
Jazyk:	angličtina
Zdroj:	Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Dec; Vol. 81 (12), pp. 2549-2558. Date of Electronic Publication: 2024 Oct 23.
DOI:	10.1161/HYPERTENSIONAHA.124.23634
Abstrakt:	Background: Cytochrome-P450 eicosanoids from arachidonic acid, including vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE, are important in regulating blood pressure, vascular tone, and cardiac and renal function. This study examined plasma 20-HETE and EETs in relation to blood pressure and vascular stiffness in a cohort of 1054 community-dwelling young adults from the Raine Study at 27 years. Methods: Plasma 20-HETE, EETs, and their hydroxylated products were measured by liquid chromatography-tandem mass spectrometry. Pulse wave velocity and aortic distensibility were measured to assess vascular stiffness. Sex differences were assessed using univariate analysis. Multiple regression models assessed the relationship between 20-HETE and systolic blood pressure (SBP) and measures of vascular stiffness. Results: The regression model for SBP showed a positive relationship with plasma 20-HETE (β, 0.092; P <0.0001), after adjusting for sex ( P <0.0001), body mass index ( P <0.0001), (ln)triglycerides ( P <0.0001), and (ln)Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) ( P =0.015), and accounted for 29% of the variance in SBP. 20-HETE was positively related to pulse wave velocity (β, 0.059; P =0.021); after adjusting for sex ( P <0.0001), SBP ( P <0.0001), (ln)triglycerides ( P =0.014), (ln)HOMA-IR ( P =0.0001), (ln)high-sensitivity C-reactive protein ( P =0.005), and age ( P =0.002), the model accounted for 34% of the variance in pulse wave velocity. 20-HETE was inversely associated with aortic distensibility (β, -0.051; P =0.029), independent of sex ( P <0.0001), SBP ( P <0.0001), and (ln)HOMA-IR ( P <0.0001); the model accounted for 25% of the variance in aortic distensibility. Plasma EETs were not significant predictors of SBP or vascular stiffness. Conclusions: In young adults, 20-HETE may play a fundamental role in regulating blood pressure and vascular stiffness independent of numerous cardiometabolic risk factors and cytochrome 450-derived EETs. Registration: URL: https://www.anzctr.org.au; Unique identifier: CTRN12617001599369. Competing Interests: None.
Databáze:	MEDLINE
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