More than a headache-somatic and mental symptom burden in spontaneous intracranial hypotension before and after surgical treatment.

Autor:	Volz F; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany., Lahmann C; Department of Psychosomatic Medicine and Psychotherapy - Center for Mental Health, Medical Center - University of Freiburg, Freiburg, Germany., Wolf K; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany., Fung C; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Lindenhofspital, Bern, Switzerland., Shah MJ; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany., Lützen N; Department of Neuroradiology, Medical Center - University of Freiburg, Freiburg, Germany., Urbach H; Department of Neuroradiology, Medical Center - University of Freiburg, Freiburg, Germany., Zander C; Department of Neuroradiology, Medical Center - University of Freiburg, Freiburg, Germany., Beck J; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany., El Rahal A; Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2024 Oct 08; Vol. 15, pp. 1421579. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).
DOI:	10.3389/fneur.2024.1421579
Abstrakt:	Introduction: Patients with spontaneous intracranial hypotension (SIH) frequently present with several symptoms and impaired mental health. This study systematically investigates the somatic and mental symptom burden of SIH and the effect of surgical treatment. Methods: In this single-center retrospective study, patients with surgical closure of a spinal cerebrospinal fluid leak between September 2022 and July 2023 completed the Somatic Symptom Scale (SSS-8), the Somatic Symptom Disorder - B Criteria Scale (SSD-12), and the Patient Health Questionnaire (PHQ-8) preoperatively and three and 6 months postoperatively. Results: Fifty-seven patients were included. All three scores showed clearly pathological values before surgery (SSS-8: 12 [IQR 6.5-16], SSD-12: 26 [IQR 19.5-33.5], PHQ-8: 11 [IQR 6.5-15]) representing a high somatic symptom burden and relevant current depression. After surgery, there was a significant and sustainable improvement (SSS-8: 8 [IQR 3-11.75], SSD-12: 12.5 [IQR 5-21.75], PHQ-8: 4.5 [IQR 2-9], p  < 0.001, respectively) that exceeded the minimal clinically important difference for every score. Conclusion: SIH presents with high somatic and mental symptom burden. Surgical treatment leads to a relevant improvement of somatic and depressive symptoms. However, even after surgical success some patients still exhibit elevated depressive scores. Depressive symptoms might be added to the typical symptomatology of SIH. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Volz, Lahmann, Wolf, Fung, Shah, Lützen, Urbach, Zander, Beck and El Rahal.)
Databáze:	MEDLINE
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