Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection.

Autor:	Hsu CY; Thunderbird School of Global Management, Arizona State University Tempe Campus, Phoenix, AZ, United States., Khachatryan LG; Department of Pediatric Diseases, N. F. Filatov Clinical Institute of Children's Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Younis NK; Department of Pharmacy, Al-Noor University College, Bartella, Iraq., Mustafa MA; Department of Medical Laboratory Techniques, University of Imam Jafar Al-Sadiq, College of Technology, Baghdad, Iraq., Ahmad N; Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka, India.; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, India.; Department of Biotechnology, School of Allied Sciences, Dev Bhoomi Uttarakhand University Dehradun, Uttarakhand, India., Athab ZH; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq., Polyanskaya AV; Department of Pediatric Diseases, N. F. Filatov Clinical Institute of Children's Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Kasanave EV; Department of Pediatric Diseases, N. F. Filatov Clinical Institute of Children's Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Mirzaei R; Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran., Karampoor S; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2024 Oct 08; Vol. 15, pp. 1456793. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).
DOI:	10.3389/fmicb.2024.1456793
Abstrakt:	The infant gut microbiota undergoes significant changes during early life, which are essential for immune system maturation, nutrient absorption, and metabolic programming. Among the various microbial metabolites, short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, produced through the fermentation of dietary fibers by gut bacteria, have emerged as critical modulators of host-microbiota interactions. SCFAs serve as energy sources for colonic cells and play pivotal roles in regulating immune responses, maintaining gut barrier integrity, and influencing systemic metabolic pathways. Recent research highlights the potential neuroprotective effects of SCFAs in pediatric populations. Disruptions in gut microbiota composition and SCFA production are increasingly associated with a range of pediatric health issues, including obesity, allergic disorders, inflammatory bowel disease (IBD), and neurodevelopmental disorders. This review synthesizes current knowledge on the role of microbiota-derived SCFAs in pediatric health, emphasizing their contributions from gut development to neuroprotection. It also underscores the need for further research to unravel the precise mechanisms by which SCFAs influence pediatric health and to develop targeted interventions that leverage SCFAs for therapeutic benefits. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hsu, Khachatryan, Younis, Mustafa, Ahmad, Athab, Polyanskaya, Kasanave, Mirzaei and Karampoor.)
Databáze:	MEDLINE
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