Neutrophils under the microscope: neutrophil dynamics in infection, inflammation, and cancer revealed using intravital imaging.

Autor:	Yam AO; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia.; Immune Biotherapeutics Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; St Vincent's School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; The Kinghorn Cancer Centre, St Vincent's Hospital, Sydney, NSW, Australia., Jakovija A; St Vincent's School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Gatt C; St Vincent's School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Chtanova T; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia.; St Vincent's School of Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Oct 08; Vol. 15, pp. 1458035. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1458035
Abstrakt:	Neutrophils rapidly respond to inflammation resulting from infection, injury, and cancer. Intravital microscopy (IVM) has significantly advanced our understanding of neutrophil behavior, enabling real-time visualization of their migration, interactions with pathogens, and coordination of immune responses. This review delves into the insights provided by IVM studies on neutrophil dynamics in various inflammatory contexts. We also examine the dual role of neutrophils in tumor microenvironments, where they can either facilitate or hinder cancer progression. Finally, we highlight how computational modeling techniques, especially agent-based modeling, complement experimental data by elucidating neutrophil kinetics at the level of individual cells as well as their collective behavior. Understanding the role of neutrophils in health and disease is essential for developing new strategies for combating infection, inflammation and cancer. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Yam, Jakovija, Gatt and Chtanova.)
Databáze:	MEDLINE
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