A Study of Cadaveric Skin Graft Harvest and Usage: An Observational Prospective Pilot Study.
| Autor: | B AP; General Surgery, Military Hospital Bareilly, Bareilly, IND.; Resident, General Surgery, INHS, Asvini, Colaba, Mumbai, IND., Vishwanath G; Plastic Surgery, Dnyandeo Yashwantrao (DY) Patil Medical College Hospital and Research Centre, Pune, IND.; Plastic Surgery, Indian Naval Hospital Ship Asvini, Mumbai, IND., Tikar CR; Urology, Nair Hospital, Mumbai, IND.; General Surgery, Indian Naval Hospital Ship Asvini, Mumbai, IND., Deshpande SG; Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.; General Surgery, Indian Naval Hospital Ship Asvini, Mumbai, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Sep 22; Vol. 16 (9), pp. e69932. Date of Electronic Publication: 2024 Sep 22 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.69932 |
| Abstrakt: | Background Burn injuries pose a significant global public health challenge, causing substantial morbidity and mortality, particularly in low- and middle-income countries. Timely and effective wound coverage is critical in treating severe burns to prevent infection, reduce pain, and promote healing. Cadaveric skin grafts (allografts) have become essential in treating extensive burn wounds, serving as temporary biological dressings to prepare the wound bed for autografting. This study aims to comprehensively analyze the process of cadaveric skin graft harvest and usage in a tertiary care setting. It seeks to evaluate the procedures, challenges, and outcomes associated with cadaveric skin grafts, contributing to optimizing burn care practices and improving patient outcomes. Methods This observational study was conducted at a tertiary care hospital and burns center with a skin bank, involving 44 cadaveric skin graft harvests and 27 applications between July 1, 2011, and June 30, 2013. The study focused on prospective donors and recipients needing cadaveric skin grafts. Inclusion criteria for donors included consent from the next of kin and the absence of infections or septicemia, while exclusion criteria included prolonged post-mortem intervals and medico-legal cases. The procedures adhered to the Euro Skin Bank protocols, encompassing retrieval, processing, storage, and usage. Data were analyzed using Epi-Info version 7.2.1 software, employing descriptive statistics for categorical variables. Ethical clearance was obtained from the university ethical committee, with mandatory written informed consent for skin donation. Results Out of 519 deaths in the tertiary care hospital, significant barriers to skin donation included septicemia, skin changes, late reporting, young age, medico-legal issues, and positive viral markers. Notably, 114 (21.97%) of next of kin refused consent. Cadaveric skin was harvested in five (11.36%) cases, with potential donors identified in 78 (15.02%) of deaths. Donors were predominantly older males, with efficient procurement processes ensuring timely harvests. The tertiary burns center facilitated 39 (88.63%) cases of cadaveric skin harvests with a skin bank, either at the donor's home or other hospitals notified to the burns center. Cadaveric skin grafts were applied in 27 cases, primarily for burns, with high graft uptake observed over 10 days. Non-healing ulcers showed 100% graft uptake. The survival rate among burn patients was 20 (74%), with deaths mainly due to sepsis and multi-organ failure. Significant barriers to obtaining consent included a lack of awareness, superstitions, social stigmas, and religious objections. Conclusion The study highlights the critical role of cadaveric skin in managing extensive wounds, particularly burns. Despite challenges in obtaining consent and limited donor availability, cadaveric skin grafts effectively prepared wound beds for autografting, contributing to improved patient outcomes. Increasing community awareness and addressing superstitions and social stigmas are essential for improving donation rates. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Ethics Committee of Maharashtra University of Health Sciences issued approval MUHS/PG-T/E1/T-Ap/1620/2012. Indian Naval Hospital Ship, Asvini, is a naval institute with postgraduate seats in general surgery affiliated with Maharashtra University of Health Sciences Nashik. The Ethics Committee of the university grants approval to all theses conducted at affiliated institutes. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, B et al.) |
| Databáze: | MEDLINE |
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