Effects of Immunotoxicity biomarkers, essential elements and vitamin D levels on the severity levels of COVID-19 disease in Turkey.

Autor:	Secerlı J; Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye., Çetinkaya S; Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye., Leblebici İS; Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye., Özdemir LA; Department of Chest Diseases, University of Health Sciences Turkey, Gülhane Research and Training Hospital, 06018 Ankara, Türkiye., Yücel Ç; Department of Pharmaceutical Biochemistry, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye., Karaismailoğlu E; Department of Biostatistics, University of Health Sciences Turkey, Gülhane Faculty of Medicine, 06018 Ankara, Türkiye., Kara U; General Intensive Care Unit, Special Acıbadem Ataşehir Hospital, 34758 İstanbul, Türkiye., Özcan A; Department of Sports Medicine, University of Health Sciences Turkey, Gülhane Faculty of Medicine, 06018 Ankara, Türkiye., Öcal N; Department of Chest Diseases, University of Health Sciences Turkey, Gülhane Research and Training Hospital, 06018 Ankara, Türkiye., Arslan Y; Department of Chest Diseases, University of Health Sciences Turkey, Gülhane Research and Training Hospital, 06018 Ankara, Türkiye., Şenkal S; General Intensive Care Unit, Special Acıbadem Ataşehir Hospital, 34758 İstanbul, Türkiye., Erdem O; Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye., Bacanlı MG; Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, 06018 Ankara, Türkiye.
Jazyk:	angličtina
Zdroj:	Toxicology research [Toxicol Res (Camb)] 2024 Oct 20; Vol. 13 (5), pp. tfae177. Date of Electronic Publication: 2024 Oct 20 (Print Publication: 2024).
DOI:	10.1093/toxres/tfae177
Abstrakt:	Many mechanisms are thought to play a role in the pathogenesis of the COVID-19 pandemic, which started in 2019 and affected the whole world. It has been claimed that a deficiency in the immune system can significantly affect the severity of COVID-19 disease. It is important that the levels of essential elements and vitamin D are at certain levels for the healthy functioning of the immune system. Therefore, in this study, it was aimed to evaluate immunotoxicity biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin (IL)-10, interferon (IFN)-γ, monocyte chemotactic protein-1 (MCP-1)), vitamin D, and essential element levels in COVID-19 patients in Turkey. According to the results of the study, it was found that the magnesium (Mg), zinc (Zn), and selenium (Se) levels decreased as the severity of the disease worsened, while the iron (Fe), and copper (Cu) levels were similar to the mild group and the control group, and the levels decreased as the disease worsened. It has also been found that vitamin D levels decrease as the severity of the disease worsens. Compared to the control group, TNF-α, MCP-1, and IFN-γ levels were found to decrease as the severity of the disease worsened. Also, it was observed that there was a significant relationship between essential metal levels and disease progression in most of the patient groups. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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