The role of non-coding RNAs in fibroblast-like synoviocytes in rheumatoid arthritis.

Autor: Zheng Y; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China., Cai X; Department of Pharmacy, Hangzhou First People's Hospital, Hangzhou, China., Ren F; Department of Pharmacy, Hangzhou Women's Hospital, Hangzhou, China., Yao Y; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2024 Oct; Vol. 27 (10), pp. e15376.
DOI: 10.1111/1756-185X.15376
Abstrakt: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast-like synoviocytes (FLSs) constitute the majority of cells in the synovial tissue, playing a crucial role in the onset of RA. Dysregulation of FLSs function is a critical strategy in treating joint damage associated with RA. Non-coding RNAs, a class of RNA molecules that do not encode proteins, participate in the development of various diseases. This article aims to review the progress in the study of long non-coding RNAs, microRNAs, and circular RNAs in FLSs. Non-coding RNAs are involved in the pathogenesis of RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, and inflammatory responses. Furthermore, non-coding RNAs also influence DNA methylation and osteogenic differentiation in FLSs. Therefore, non-coding RNAs hold promise as biomarkers for diagnosing RA. Targeting non-coding RNAs in FLSs locally represents a potential strategy for future therapies in RA.
(© 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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