Assessment of Optical Attenuation and Skin Thickness in Type 2 Diabetes Mellitus Patients Using Optical Coherence Tomography.

Autor: Chen M; Shanghai Institute for Interventional Medical Devices, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China., Shen Y; Shanghai Institute for Interventional Medical Devices, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China., Zhu J; Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Su T; Photonic View Technology Co. Ltd., Shanghai, China., Zhang Y; Photonic View Technology Co. Ltd., Shanghai, China., Wang W; Photonic View Technology Co. Ltd., Shanghai, China., Chen C; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhou L; Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Dec; Vol. 17 (12), pp. e202400267. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1002/jbio.202400267
Abstrakt: Diabetes management often involves invasive blood glucose monitoring, which can be uncomfortable for patients. Non-invasive techniques like multiple μ-spatially offset Raman spectroscopy (mμSORS) offer a promising alternative. To provide clinical data supporting mμSORS, we conducted a clinical trial with 198 participants to evaluate mμSORS for non-invasive blood glucose measurement. Using Optical Coherence Tomography, we studied skin thickness and optical attenuation in 172 diabetic and 26 healthy subjects. Results showed thicker stratum corneum and stratum spinosum (SS) in diabetics. Epidermal thickness increased with age and body mass index (BMI), decreased with skin brightness, and varied minimally with gender. Optical attenuation in SS was lower in diabetics, decreased with increasing a*, and was minimally affected by gender and BMI but increased with age in the upper dermis. These findings support mμSORS for accurate non-invasive glucose monitoring.
(© 2024 The Author(s). Journal of Biophotonics published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: