Volatile organic compounds in exhaled breath, blood, and urine detected in patients with thyroid carcinoma using gas chromatography-ion mobility spectrometry - a pilot study.

Autor:	Al-Difaie ZJJ; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Scheepers MHMC; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Engelen SME; Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Lubbers T; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Havekes B; Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, Maastricht, The Netherlands.; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands., Bouvy ND; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.; Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of breath research [J Breath Res] 2024 Nov 26; Vol. 19 (1). Date of Electronic Publication: 2024 Nov 26.
DOI:	10.1088/1752-7163/ad89ef
Abstrakt:	The differentiation between malignant and benign thyroid nodules represents a significant challenge for clinicians globally. The identification of volatile organic compounds (VOCs) has emerged as a novel approach in the field of cancer diagnosis. This prospective pilot study aims to identify VOCs in exhaled breath, blood, and urine that can differentiate benign from malignant thyroid nodules using gas chromatography-ion mobility spectrometry (GC-IMS). Patients with thyroid nodules scheduled for surgery were enrolled at the Maastricht University Medical Center (MUMC+). Breath samples were analyzed using a BreathSpec GC-IMS machine (G.A.S. Dortmund, Germany), specifically designed for breath analysis. All blood and urine samples were analyzed using a separate GC-IMS device, the FlavourSpec® (G.A.S., Dortmund, Germany). In this proof-of-concept study, 70 consecutive patients undergoing thyroid surgery at MUMC+ were included. Of these patients, 29 were confirmed to have thyroid cancer after surgical resection. The overall analysis did not reveal statistically significant differences in VOCs in breath, urine and blood, between patients with benign and malignant thyroid cancer. This proof-of-concept study demonstrated that GC-IMS could not effectively differentiate between the VOC profiles of malignant and benign thyroid nodules. However, due to the small sample size of this study, larger prospective studies are needed to investigate the potential of using VOCs to distinguish between benign and malignant thyroid nodules. Additionally, future research should focus on identifying potential confounding factors that may influence patient VOC profiles. (NCT04883294). (Creative Commons Attribution license.)
Databáze:	MEDLINE
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