Histologic parameters driving completion thyroidectomy for papillary thyroid carcinoma in a high-volume institution: A retrospective observational study.

Autor: Rossi L; Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy. Electronic address: rossi.leonardo.phd@gmail.com., De Palma A; Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy. Electronic address: depalma.and@gmail.com., Ambrosini CE; Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy. Electronic address: carloeambrosini@gmail.com., Fregoli L; Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy. Electronic address: lorenzofregoli@gmail.com., Matrone A; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: antonio.matrone@med.unipi.it., Elisei R; Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: rossella.elisei@med.unipi.it., Materazzi G; Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy. Electronic address: gmaterazzi@yahoo.com.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2024 Oct 15; Vol. 239, pp. 116016. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1016/j.amjsurg.2024.116016
Abstrakt: Background: When the histological examination indicates papillary thyroid carcinoma (PTC), there is no unanimity on the need to proceed with completion thyroidectomy (CT). This study aims to assess the histologic parameters that influenced the decision to perform CT.
Materials and Methods: This study included PTC patients who underwent thyroid lobectomy between 2019 and 2022. Group A included patients who underwent thyroid lobectomy without further treatments, whereas Group B included those who underwent CT based on histological findings. Differences in terms of histologic parameters were analyzed.
Results: Group A included 291 patients (68.3 ​%), whereas Group B 135 patients (31.7 ​%). Multivariate analysis identified associations between CT and tumor size (p ​< ​0.001), aggressive variant (p ​= ​0.009), and vascular invasion (p ​< ​0.001). ROC curve analysis established a tumor size cut-off of 21 ​mm for CT. At ROC curve analysis, the cut-off number of aggressive factors required for CT was 2.
Conclusion: A thorough comprehensive assessment encompassing all pathological characteristics might be necessary in case of PTC with aggressive histologic features after thyroid lobectomy.
Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest related to the research presented in this article. They have not received funding or support from organizations that may benefit from or be influenced by the research findings. Additionally, they have no affiliations or financial interests with companies or entities that may have a direct interest in the discussed research. The authors confirm that this work was conducted independently and that the opinions and conclusions expressed are solely based on the presented data and analysis.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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