Seroprevalence of diphtheria, tetanus and pertussis antibodies and Tdap vaccination in pregnant women in Greece - A cross- sectional study.

Autor: Papailiou S; National and Kapodistrian University of Athens, School of Medicine, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece. Electronic address: valia.papailiou@gmail.com., Soldatou A; National and Kapodistrian University of Athens, School of Medicine, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece., Marmarinos A; National and Kapodistrian University of Athens, School of Medicine, Laboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece., Avgeris M; National and Kapodistrian University of Athens, School of Medicine, Laboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece., Papathoma E; Neonatal Intensive Care Unit, 'Alexandra' University and State Maternity Hospital, Athens, Greece., Sindos M; National and Kapodistrian University of Athens, School of Medicine, First Department of Obstetrics and Gynaecology, 'Alexandra' University and State Maternity Hospital, Athens, Greece., Georgantzi S; National and Kapodistrian University of Athens, School of Medicine, First Department of Obstetrics and Gynaecology, 'Alexandra' University and State Maternity Hospital, Athens, Greece., Rodolakis Α; National and Kapodistrian University of Athens, School of Medicine, First Department of Obstetrics and Gynaecology, 'Alexandra' University and State Maternity Hospital, Athens, Greece., Iacovidou N; National and Kapodistrian University of Athens, School of Medicine, Neonatal Department, 'Aretaieio' Hospital, Athens, Greece., Gourgiotis D; National and Kapodistrian University of Athens, School of Medicine, Laboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece., Tsolia M; National and Kapodistrian University of Athens, School of Medicine, Second Department of Pediatrics, Aglaia Kiriakou Children's Hospital, Athens, Greece.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Dec 02; Vol. 42 (26), pp. 126435. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1016/j.vaccine.2024.126435
Abstrakt: Objectives: We performed a cross- sectional study in two maternity hospitals in Athens, Greece between 2017 and 2019 assessing seroprevalence and Geometric Mean Titres (GMTs) of diphtheria, pertussis and tetanus antibodies in pregnant women and recorded adherence to Greek National Immunization Program (NIP) regarding Tdap vaccination in pregnancy.
Methods: Blood samples were collected from women in labour and anti- diphtheria, tetanus and pertussis toxin IgG antibodies were measured by Elisa kits. Seropositivity was defined as anti-diphtheria and anti- tetanus toxin IgG levels ≥0.1, and anti- pertussis >50 IU/mL. Seroprevalence and GMTs were calculated according to demographic factors. Tdap vaccination before and during pregnancy was self-reported by study participants.
Results: We analysed 253 blood samples and paired questionnaires. Seropositivity was 57.7 % for diphtheria. The lowest rate (38.2 %) was observed in the youngest age group (≤25 years). Increasing age was associated with higher seroprevalence (p = 0.036). 12.5 % of women were seropositive against pertussis. Most were seropositive for tetanus (92.7 %). Anti-pertussis GMTs were 16.98, anti-diphtheria 0.13 and anti- tetanus GMTs 0.63 IU/mL. Women born in Greece and with higher educational level had higher antibodies against tetanus (p = 0.004 & 0.004 respectively). 3/253 (1.2 %) of women assessed reported Tdap vaccination during pregnancy.
Conclusion: Seropositivity rates were low for diphtheria and pertussis among pregnant women. In addition, less than 2 % were vaccinated with Tdap despite recommendation by Greek NIP. Therefore, many infants end up unprotected during the first months of life. Our study highlights the urgent need for national campaigns targeting to completion of childhood immunization and information of the public about safety and importance of Tdap vaccination in pregnancy.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Maria Tsolia reports financial support was provided by GSK.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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