Circulating Extracellular Matrix Products as Indicators of Disease Burden and Predictors of Disease Course in Ulcerative Colitis.

Autor:	Poulsen A; Digestive Disease Center, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Digestive Diseases, Transplantation and General Surgery, Section for IBD, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark., Alexdóttir MS; Biomarkers and Research, Nordic Bioscience, Herlev, Denmark., Riis LB; Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Pehrsson M; Biomarkers and Research, Nordic Bioscience, Herlev, Denmark., Sørensen LT; Digestive Disease Center, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark., Krarup PM; Digestive Disease Center, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark., Bay-Jensen AC; Biomarkers and Research, Nordic Bioscience, Herlev, Denmark., Karsdal MA; Biomarkers and Research, Nordic Bioscience, Herlev, Denmark., Stidham RW; Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Burisch J; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Gastrounit - Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Mortensen JH; Biomarkers and Research, Nordic Bioscience, Herlev, Denmark., Seidelin JB; Department of Digestive Diseases, Transplantation and General Surgery, Section for IBD, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Gastroenterology and Hepatology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
Jazyk:	angličtina
Zdroj:	Inflammatory bowel diseases [Inflamm Bowel Dis] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI:	10.1093/ibd/izae244
Abstrakt:	Background: Ulcerative colitis (UC) is characterized by recurrent inflammation and challenging disease monitoring, with invasive endoscopy as the primary diagnostic tool despite the inadequacy of standard noninvasive biomarkers. This study evaluates serum extracellular matrix (ECM) fragments, which reflect the remodeling of mucosa and submucosa, as potential indicators of disease burden and treatment efficacy. We aim to determine whether serum ECM levels correlate with the extent and severity and predict treatment response. Methods: We conducted a prospective study comparing serum ECM formation (PRO-C3, PRO-C7, PRO-C11, PRO-C22), turnover (PRO-C4), and degradation markers (C1M, C3M, C4M, C7M) at Weeks 0, 12, and 24 in 49 UC patients and 50 healthy controls measured by enzyme-linked immunosorbent assay. Results: ECM biomarkers, notably PRO-C11, differentiated UC patients from controls (area under the curve [AUC] 0.77), and PRO-C3 predicted endoscopic treatment response vs nonresponse (AUC 0.74). C7M separated moderate from severe disease in endoscopy (AUC 0.74) as well as mild from severe disease (AUC 0.84), as did the ratio C7M/PRO-C7 (AUC 0.82). Combining new and conventional markers, including hemoglobin, C-reactive protein, PRO-C3, and PRO-C22, achieved a combined AUC of 0.84 for predicting 24-week endoscopic response, adding index endoscopic activity increased the AUC to 0.92 compared to an AUC of 0.84 for endoscopy alone. Conclusions: Soluble ECM fragments reflect endoscopic disease severity and extent and are also predictive of therapeutic efficacy. They may as well reflect degenerative aspects of UC and may as such be future therapeutic targets aimed at prevention of intestinal damage. (© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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