Systemic lupus international collaborating clinics-2012 and European league against rheumatism/American college of rheumatology-2019 classification criteria for systemic lupus erythematosus associated with childhood-onset auto-immune cytopenia.

Autor: Granel J; Pediatric Department, Bordeaux University Hospital, Bordeaux, France.; Centre de Référence des Rhumatismes Inflammatoires et maladies Auto-Immunes Systémiques rares de l'Enfant (RAISE), Bordeaux, France.; Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE), Bordeaux, France., Fernandes H; Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE), Bordeaux, France., Richer O; Pediatric Department, Bordeaux University Hospital, Bordeaux, France.; Centre de Référence des Rhumatismes Inflammatoires et maladies Auto-Immunes Systémiques rares de l'Enfant (RAISE), Bordeaux, France., Clet J; Pediatric Department, Bordeaux University Hospital, Bordeaux, France.; Centre de Référence des Rhumatismes Inflammatoires et maladies Auto-Immunes Systémiques rares de l'Enfant (RAISE), Bordeaux, France., Dubrasquet M; Pediatric Department, Bordeaux University Hospital, Bordeaux, France., Pillet P; Pediatric Department, Bordeaux University Hospital, Bordeaux, France.; Centre de Référence des Rhumatismes Inflammatoires et maladies Auto-Immunes Systémiques rares de l'Enfant (RAISE), Bordeaux, France., Aladjidi N; Pediatric Department, Bordeaux University Hospital, Bordeaux, France.; Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE), Bordeaux, France.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2024 Dec; Vol. 33 (14), pp. 1605-1610. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1177/09612033241296471
Abstrakt: Introduction: Systemic Lupus Erythematosus (SLE) can be diagnosed using the 2012 criteria of the Systemic Lupus International Collaborating Clinics (SLICC) and, more recently, the 2019 criteria of the European League Against Rheumatism/American College of Rheumatology (EULAR/ACR). Hematological involvement is scored differently by these classifications. Our objective was to compare both criteria in a cohort of children with autoimmune cytopenia (AIC)-associated SLE.
Method: We included 79 patients with childhood-onset AIC as the first manifestations of SLE.
Results: The median age at SLE diagnosis was 14.5 years (1.1-21.4 years). The SLICC criteria were fulfilled by 76/79 (96%) patients and the EULAR/ACR criteria by 72/79 (91%) patients during follow-up. The SLICC and EULAR/ACR criteria were discordant (not concomitantly fulfilled) in 25/79 (32%) patients. Non-hematological clinical manifestations were more frequently observed in SLE diagnosis when the criteria were concordant (30/54, 56%) than when they were not (5/25, 20%) ( p = 0.004). In 16/25 (64%) discordant patients, the SLICC criteria allowed earlier diagnosis of SLE. Finally, the attribution of a maximum weight of 6 to the hematological involvement of the EULAR/ACR criteria increased the sensitivity thereof from 63/79 (80%) to 76/79 (96%) in our population.
Conclusion: The SLICC 2012 and EULAR/ACR 2019 criteria do not effectively diagnose SLE in children when AIC is the predominant feature. The SLICC criteria appear to be more effective in this population of SLE patients. An increase in the maximum weight of hematological involvement to 6 increases the sensitivity of the EULAR/ACR criteria for SLE diagnosis in children.
Competing Interests: Declaration of conflicting interestsThe author(s) declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje