Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations with Chlamydia Outcomes.

Autor:	Yu H; British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada., Geisler WM; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Dai C; British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada., Gupta K; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Cutter G; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA., Brunham RC; British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI:	10.1093/infdis/jiae519
Abstrakt:	We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C. trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution versus persisting infection before treatment (all P< .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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