| Autor: |
Ye M; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xiaojx@lzu.edu.cn.; College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, P. R. China.; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China., Fan Y; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xiaojx@lzu.edu.cn.; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China., Fu C; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xiaojx@lzu.edu.cn.; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China., He H; College of School of Life Sciences, Lanzhou University, Lanzhou 730000, P. R. China. hehuix@lzu.edu.cn.; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China., Xiao J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xiaojx@lzu.edu.cn.; College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, P. R. China.; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China. |
| Abstrakt: |
Treating sunburn and other UV-induced skin damage issues remains a significant challenge in the field of dermatology. In this study, we synthesized a highly bioactive recombinant type III collagen (rCol III) to accelerate the healing of UV-damaged skin. The high-purity rCol III demonstrated excellent biocompatibility and bioactivity, significantly promoting the adhesion, proliferation, and migration of HFF-1 cells. In a mouse UV-damage model, Combo evaluations demonstrated that rCol III contributed to restore transepidermal water loss (TEWL) values of UV-damaged skin to normal levels. Histological analysis further confirmed that rCol III substantially accelerated skin repair by enhancing collagen regeneration. Additionally, rCol III facilitated the regeneration of zebrafish tail fin tissue and alleviated shrinkage caused by excessive UV exposure. The biocompatible and bioactive rCol III offers a novel strategy for treating UV-induced skin damage, holding immense potential for applications in skin tissue engineering. |
