Biological Characterization of Ti6Al4V Additively Manufactured Surfaces: Comparison Between Ultrashort Laser Texturing and Conventional Post-Processing.

Autor: Sartori M; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy., Bregoli C; Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE), (Consiglio Nazionale delle Ricerche - CNR), Via Gaetano Previati, 1/E, Lecco, 23900, Italy., Carniato M; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy., Cavazza L; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy., Maglio M; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy., Giavaresi G; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy., Biffi CA; Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE), (Consiglio Nazionale delle Ricerche - CNR), Via Gaetano Previati, 1/E, Lecco, 23900, Italy., Fiocchi J; Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE), (Consiglio Nazionale delle Ricerche - CNR), Via Gaetano Previati, 1/E, Lecco, 23900, Italy., Gruppioni E; INAIL Centro Protesi, Via Rabuina 14, Vigorso di Budrio, Bologna, 40054, Italy., Tuissi A; Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE), (Consiglio Nazionale delle Ricerche - CNR), Via Gaetano Previati, 1/E, Lecco, 23900, Italy., Fini M; Scientific Direction, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, 40136, Italy.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Oct 22, pp. e2402873. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1002/adhm.202402873
Abstrakt: Among Additive Manufacturing (AM) technologies, Laser Powder Bed Fusion (LPBF) has made a great contribution to optimizing the production of customized implant materials. However, the design of the ideal surface topography, capable of exerting the best biological effect without drawbacks, is still a subject of study. The aim of the present study is to topographically and biologically characterize AM-produced Ti6Al4V ELI (Extra Low Interstitial) samples by comparing different surface finishing. Vertically and horizontally samples are realized by LPBF with four surface finishing conditions (as-built, corundum-sandblasted, zirconia-sandblasted, femtosecond laser textured). Bioactivity in vitro tests are performed with human osteoblasts evaluating morphology, metabolic activity, and differentiation capabilities in direct contact with surfaces. Scanning electron microscope and profilometry analysis are used to evaluate surface morphology and samples' roughness with and without cells. All tested surfaces show good biocompatibility. The influence of material surface features is evident in the early evaluation, with the most promising results of morphological study for laser texturing. Deposition orientations seem to influence metabolic activities, with XZ orientation more effective than XY. Current data provide the first positive feedback on the biocompatibility of laser texturing finishing, still poorly described in the literature, and support the future clinical development of devices produced with a combination of LPBF and different finishing treatments.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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