DIONYSUS: a database of protein-carbohydrate interfaces.

Autor:	Gheeraert A; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Bailly T; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Ren Y; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France.; Université Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France., Hamraoui A; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France.; Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Universite Paris, 75005 Paris, France., Te J; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Vander Meersche Y; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Cretin G; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Leon Foun Lin R; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Gelly JC; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Pérez S; Centre de Recherches sur les Macromolécules Végétales, University Grenoble Alpes, CNRS, UPR, 5301 Grenoble, France., Guyon F; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France., Galochkina T; Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France.
Jazyk:	angličtina
Zdroj:	Nucleic acids research [Nucleic Acids Res] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.
DOI:	10.1093/nar/gkae890
Abstrakt:	Protein-carbohydrate interactions govern a wide variety of biological processes and play an essential role in the development of different diseases. Here, we present DIONYSUS, the first database of protein-carbohydrate interfaces annotated according to structural, chemical and functional properties of both proteins and carbohydrates. We provide exhaustive information on the nature of interactions, binding site composition, biological function and specific additional information retrieved from existing databases. The user can easily search the database using protein sequence and structure information or by carbohydrate binding site properties. Moreover, for a given interaction site, the user can perform its comparison with a representative subset of non-covalent protein-carbohydrate interactions to retrieve information on its potential function or specificity. Therefore, DIONYSUS is a source of valuable information both for a deeper understanding of general protein-carbohydrate interaction patterns, for annotation of the previously unannotated proteins and for such applications as carbohydrate-based drug design. DIONYSUS is freely available at www.dsimb.inserm.fr/DIONYSUS/. (© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)
Databáze:	MEDLINE
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