Effect of a multidisciplinary lifestyle intervention on body composition in people with osteoarthritis: Secondary analysis of the "Plants for Joints" randomized controlled trial.

Autor:	Wagenaar CA; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands.; Amsterdam UMC Location University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Rheumatology and Immunology Center, Amsterdam, the Netherlands., Walrabenstein W; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands.; Amsterdam UMC Location University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Rheumatology and Immunology Center, Amsterdam, the Netherlands., de Jonge CS; Amsterdam UMC Location University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands., Bisschops M; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands., van der Leeden M; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands.; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Boelelaan 1117, Amsterdam, the Netherlands.; Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands., van der Esch M; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands.; Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Faculty of Health, Amsterdam, the Netherlands., Weijs PJM; Department of Nutrition and Dietetics, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands.; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Nutrition and Dietetics, Boelelaan 1117, Amsterdam, the Netherlands., Troelstra MA; Amsterdam UMC Location University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands., Korteweg MA; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands., Nederveen AJ; Amsterdam UMC Location University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands.; Amsterdam Movement Sciences Research Institute, Amsterdam, the Netherlands., van Schaardenburg D; Reade Center for Rheumatology and Rehabilitation, Amsterdam, the Netherlands.; Amsterdam UMC Location University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Rheumatology and Immunology Center, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2024 Oct 01; Vol. 6 (4), pp. 100524. Date of Electronic Publication: 2024 Oct 01 (Print Publication: 2024).
DOI:	10.1016/j.ocarto.2024.100524
Abstrakt:	Objective: The Plants for Joints (PFJ) intervention significantly improved pain, stiffness, and physical function, and metabolic outcomes, in people with metabolic syndrome-associated osteoarthritis (MSOA). This secondary analysis investigated its effects on body composition. Method: In the randomized PFJ study, people with MSOA followed a 16-week intervention based on a whole-food plant-based diet, physical activity, and stress management, or usual care. For this secondary analysis, fat mass, muscle mass, and bone mineral density were measured using dual-energy X-ray absorptiometry (DEXA) for all participants. Additionally, in a subgroup ( n  ​= ​32), hepatocellular lipid (HCL) content and composition of visceral adipose tissue (VAT) were measured using magnetic resonance spectroscopy (MRS). An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyse between-group differences. Results: Of 66 people randomized, 64 (97%) completed the study. The PFJ group experienced significant weight loss (-5.2 ​kg; 95% CI -6.9, -3.6) compared to controls, primarily from fat mass reduction (-3.9 ​kg; 95% CI -5.3 to -2.5). No significant differences were found in lean mass, muscle strength, or bone mineral density between groups. In the subgroup who underwent MRI scans, the PFJ group had a greater reduction in HCL (-6.5%; 95% CI -9.9, 3.0) compared to controls, with no observed differences in VAT composition. Conclusion: The PFJ multidisciplinary intervention positively impacted clinical and metabolic outcomes, and appears to significantly reduce body fat, including liver fat, while preserving muscle mass and strength. Competing Interests: Authors CAW, WW, and DvS hold shares in Plants for Health, a limited liability company, which aims to have a positive impact on society and the environment and provide an adapted version of the Plants for Joints program as an additional treatment option for people with rheumatic conditions. All other authors report no conflict of interest. (© 2024 The Author(s).)
Databáze:	MEDLINE
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