Navigating Diagnostic Challenges: Primary Pulmonary Choriocarcinoma Depicted by Fluorodeoxyglucose (FDG)-Positron Emission Tomography-Computed Tomography (PET/CT).

Autor:	Abu Aljaaz F; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, JOR., Moghrabi S; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, JOR., Al-Adhami D; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, JOR., Al-Shatti M; Department of Pathology, King Hussein Cancer Center (KHCC), Amman, JOR., Al-Ibraheem A; Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, JOR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 21; Vol. 16 (9), pp. e69866. Date of Electronic Publication: 2024 Sep 21 (Print Publication: 2024).
DOI:	10.7759/cureus.69866
Abstrakt:	This report explores a noteworthy case diagnosed with primary pulmonary choriocarcinoma (PPC), a rare and often fatal non-seminomatous germ cell tumor. Initially misdiagnosed as lung adenocarcinoma, this case underscores the diagnostic complexities associated with PPC. A 44-year-old woman initially misdiagnosed with non-small lung cancer underwent unsuccessful chemoradiation. Emergency presentation with gastrointestinal bleeding revealed intestinal intussusception and severe anemia, rendering her ineligible for surgery. A thorough assessment, including fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), uncovered an aggressive neoplastic pattern. A subsequent biopsy confirmed PPC. Ten cycles of chemotherapy (cisplatin and etoposide on day 1, followed by etoposide, methotrexate, and dactinomycin on day 8) were offered. A complete metastatic response and a marked primary tumor reduction were evident at the end of therapy by PET/CT. Our findings underscore the importance of whole-body FDG PET/CT in comprehensively evaluating disease extent, displaying aggressive and atypical patterns, and offering guidance in complicated cases under multidisciplinary settings. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Abu Aljaaz et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu