Antioxidant activity of Schiff base ligands using the DPPH scavenging assay: an updated review.

Autor:	Rana MS; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Rayhan NMA; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Emon MSH; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Islam MT; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Rathry K; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Hasan MM; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Islam Mansur MM; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Srijon BC; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Islam MS; Department of Pharmacy, University of Rajshahi Rajshahi-6205 Bangladesh., Ray A; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Rakib MA; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Islam A; Department of Biochemistry and Molecular Biology, University of Rajshahi Rajshahi-6205 Bangladesh., Kudrat-E-Zahan M; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Hossen MF; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh., Asraf MA; Department of Chemistry, University of Rajshahi Rajshahi-6205 Bangladesh.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 Oct 21; Vol. 14 (45), pp. 33094-33123. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024).
DOI:	10.1039/d4ra04375h
Abstrakt:	Schiff base ligands, formed from primary amines and carbonyl compounds, are potential antioxidants because they scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals via hydrogen atom transfer (HAT) and single electron transfer (SET) routes. This review aims to help design, synthesize, and discuss the antioxidant activity of Schiff base ligands based on their structure. This study critically discussed the solvent effect and the structural changes of Schiff base ligands responsible for DPPH scavenging activity, such as proton donating, electron-donating, and electron-withdrawing substituents, conjugation and ring structure. The ligands with electron-donating substituent groups in the phenolic ring demonstrated greater activity by readily stabilizing the radical and some of them showed higher activity than the standard. The activity also depends on the solvent used; the activity increases in those solvents that promote the proton and electron donation of the Schiff base. Schiff bases are most important due to their versatile applications, which can be explained by their antioxidant activity. The data led to the conclusion that the Schiff base ligand will serve as a source of synthetic antioxidants. There should be lots of scope for research on the antioxidant activity of Schiff bases. This review will assist researchers in studying Schiff base-based antioxidants and their applications. All the data analyzed in this paper was found from in vitro tests; for more clearance supplementary tests and in vivo investigations are crucial. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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