The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition.

Autor: Baltic S; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia., Nedeljkovic D; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia., Todorovic N; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia., Ratgeber L; Faculty of Health Sciences, University of Pecs, Pecs, Hungary., Betlehem J; Faculty of Health Sciences, University of Pecs, Pecs, Hungary., Acs P; Faculty of Health Sciences, University of Pecs, Pecs, Hungary., Stajer V; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia., Ostojic SM; Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.; Faculty of Health Sciences, University of Pecs, Pecs, Hungary.; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway.
Jazyk: angličtina
Zdroj: Journal of nutrition and metabolism [J Nutr Metab] 2024 Oct 14; Vol. 2024, pp. 7815807. Date of Electronic Publication: 2024 Oct 14 (Print Publication: 2024).
DOI: 10.1155/2024/7815807
Abstrakt: The main objective of this pilot study was to compare the effects of short-term supplementation with a mixture containing creatine and guanidinoacetic acid (GAA) versus creatine alone on body composition indices in men and women. Twenty-three apparently healthy young adults (mean age: 21.4 ± 0.6 years; 10 females) were randomly assigned to receive either a mixture (consisting of 2 g of creatine monohydrate and 2 g of GAA) or an equimolar amount of creatine monohydrate in a pretest-posttest control group experimental crossover design. After the intervention period, participants entered a 2-week washout phase to minimize any residual effects of the treatment. Body composition was assessed using a multifrequency bioelectrical impedance analysis at baseline (preadministration) and at the 7-day follow-up (postadministration). A significant interaction effect was found for extracellular mass ( p =0.009), with creatine-GAA outperforming creatine in augmenting extracellular mass across the whole sample. In the male subsample, creatine was superior to the mixture in increasing intracellular water ( p =0.049), whereas the mixture increased extracellular mass, contrasting with the reduction observed with creatine alone ( p =0.008). No significant differences between interventions were reported in the female subsample ( p > 0.05), indicating that adding GAA to creatine may produce unique, sex-specific effects on body composition. Further studies are needed to validate our findings across different demographic cohorts and various interventional regimens.
Competing Interests: S.M.O. serves as a member of the Scientific Advisory Board on Creatine in Health and Medicine (AlzChem LLC). S.M.O. co-owns the patent “Supplements Based on Liquid Creatine” at the European Patent Office (WO2019150323 A1) and has a patent application for “Composition Comprising Creatine for Use in Telomere Lengthening” at the U.S. Patent and Trademark Office (#63/608,850). S.M.O. has received research support related to creatine over the past 36 months from the Serbian Ministry of Education, Science, and Technological Development; the Provincial Secretariat for Higher Education and Scientific Research; AlzChem GmbH; ThermoLife International; and Hueston Hennigan LLP. S.M.O. does not own stocks or shares in any organization. S.B., D.N., N.T., L.R., J.B., P.A., and V.S. declare no conflicts of interest that could have appeared to influence the authorship of this paper.
(Copyright © 2024 Sonja Baltic et al.)
Databáze: MEDLINE
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