Associations between the geriatric nutritional risk index and the risk of and mortality associated with chronic kidney disease in older individuals.

Autor: Zou P; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China.; The Second Clinical School, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhang Y; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China., Chen L; Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Liu M; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China., Nie H; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China., Gao H; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China., Zhang C; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China., Yan J; Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yanjinhua2013@outlook.com.; Key Laboratory of Vascular Aging, Tongji Hospital, Tongji Medical College, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, PR China. yanjinhua2013@outlook.com.
Jazyk: angličtina
Zdroj: BMC public health [BMC Public Health] 2024 Oct 21; Vol. 24 (1), pp. 2893. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1186/s12889-024-20283-5
Abstrakt: Background: Malnutrition is a complication of chronic kidney disease (CKD). Whether malnutrition, assessed via the geriatric nutritional risk index (GNRI), is associated with the incidence and risk of CKD in older individuals remains unclear.
Methods: Data from the National Health and Nutrition Examination Survey and the UK Biobank database were used. Older participants over 60 years old with available data for GNRI assessment and CKD diagnosis were enrolled. Logistic regression models and Cox regression models were used to assess associations between the geriatric nutritional risk index and the risk of and mortality associated with CKD.
Results: This study enrolled 13,162 participants from the NHANES and 66,326 participants from the UK Biobank. We identified 6,135 and 16,662 CKD patients in the NHANES and UK Biobank, respectively, with the majority being male (74% in the NHANES and 52% in the UK Biobank). The average age of CKD patients was 72.3 (SD 7.2) years in the NHANES and 64.9 (SD 2.9) years in the UK Biobank. The median follow-up times of older CKD patients were 81 months and 162 months in the NHANES and UK Biobank, respectively. According to the cross-sectional analysis, individuals with a lower GNRI had an increased likelihood of having CKD, with odds ratios of 1.38 (95% CI: 1.05-1.80, P = 0.020) in the NHANES and 2.35 (95% CI: 1.89-2.92, P < 0.001) in the UK Biobank. According to our analysis of the risk of incident CKD in the UK Biobank, a lower GNRI was associated with a greater incidence of CKD (HR: 1.11, 95% CI: 1.04-1.18; P = 0.002). According to the analysis of the risk of mortality, a lower GNRI was associated with an increased risk of death among older CKD patients (NHANES: HR: 1.69, 95% CI: 1.13-2.53, P = 0.011; UK Biobank: HR: 2.28, 95% CI: 1.94-2.69, P < 0.001).
Conclusion: Malnutrition assessed by the GNRI was significantly and independently associated with the incidence of CKD. Moreover, CKD patients with malnutrition also have a high risk of mortality.
(© 2024. The Author(s).)
Databáze: MEDLINE
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