The Inducible TGFβ2 Ocular Hypertension Mouse Model.
| Autor: | McDowell CM; Department of Ophthalmology, University of Wisconsin-Madison, Madison, WI, USA. cmmcdowell@wisc.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2858, pp. 123-129. |
| DOI: | 10.1007/978-1-0716-4140-8_11 |
| Abstrakt: | There is a great need for the development of mouse models of ocular hypertension. Here, we describe an inducible mouse model of ocular hypertension that produces a homogeneous intraocular pressure (IOP) response and can be induced in any mouse strain of choice without the need for extensive breeding. The procedure utilizes an ocular hypertension and glaucoma-relevant transgene, bioactivated TGFβ2, and an adenovirus 5 virus with select tropism for the trabecular meshwork (TM). (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Databáze: | MEDLINE |
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