Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea.

Autor: Ha JH; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Shin JI; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Biomedicine & Health Sciences and Integrated Research Center for Genomic Polymorphism, Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Kim KM; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Choi JG; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Trinh MP; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Anh WJ; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Kang KM; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Kang HL; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Byun JH; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Laboratory Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea., Boonyanugomol W; Department of Sciences and Liberal Arts, Mahidol University, Amnatcharoen Campus, Amnatcharoen, Thailand., Kwon KW; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Jung MH; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Baik SC; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea., Lee WK; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea. wklee@gnu.kr.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea. wklee@gnu.kr.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea. wklee@gnu.kr., Shin MK; Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Republic of Korea. mkshin@gnu.kr.; Fastidious Specialized Pathogen Resources Bank, A Member of the National Culture Collection for Pathogens, Gyeongsang National University Hospital, Jinju, Republic of Korea. mkshin@gnu.kr.; Department of Convergence Medical Science, Gyeongsang National University, Jinju, Republic of Korea. mkshin@gnu.kr.
Jazyk: angličtina
Zdroj: Folia microbiologica [Folia Microbiol (Praha)] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1007/s12223-024-01205-9
Abstrakt: Escherichia coli is a significant pathogen in extraintestinal infections, and ESBL-producing E. coli poses a major clinical challenge due to its antibiotic resistance. This study comprehensively analyzed E. coli isolates from urine and blood samples of patients with urinary tract and bloodstream infections at three major tertiary hospitals in South Korea. The goal was to provide insights into the distribution, antibiotic resistance, and virulence factors of these strains. Our analysis identified CTX-M and TEM as the dominant ESBL types, found in 71.7% and 61.7% of isolates, respectively, with 46.7% showing co-occurrence. Multilocus sequence typing (MLST) revealed the predominance of high-risk clones such as ST131, ST69, ST73, and ST95, with rare sequence types like ST410 and ST405 also identified. The high prevalence of virulence factors, including iutA (80.8%) and kpsMII (74.2%), further highlights the complexity of these strains. In addition, 38.3% of clinical isolates contained a combination of siderophore, adhesin, protectin, and toxin-related genes. There was no significant difference between urinary tract and bloodstream infections or regional differentiation in Korea. This study highlights the importance of controlling ESBL-producing E. coli infections, especially given the increasing incidence among patients with underlying medical conditions and older adults who are more susceptible to urinary tract infections. These findings serve as valuable indicators for pathogen analysis, especially those harboring antibiotic resistance and toxin genes. The insights gained are expected to contribute significantly to the development of infectious disease prevention and control strategies.
(© 2024. Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.)
Databáze: MEDLINE
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