A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI.

Autor: Callewaert B; Center for Molecular and Vascular Biology (CMVB), Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium; Biomedical MRI unit, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium., Gsell W; Biomedical MRI unit, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium., Lox M; Center for Molecular and Vascular Biology (CMVB), Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium., Himmelreich U; Biomedical MRI unit, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium., Jones EAV; Center for Molecular and Vascular Biology (CMVB), Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium; School for Cardiovascular Diseases (CARIM), Department of Cardiology, Maastricht University, 6200 Maastricht, the Netherlands. Electronic address: liz.jones@kuleuven.be.
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2024 Nov; Vol. 202, pp. 106709. Date of Electronic Publication: 2024 Oct 19.
DOI: 10.1016/j.nbd.2024.106709
Abstrakt: Endothelial dysfunction is considered a key element in the early pathogenesis of neurodegenerative disorders. Dysfunction of the cerebral endothelial cells can result in dysregulation of cerebral perfusion and disruption of the Blood Brain Barrier (BBB), leading to brain damage, neurodegeneration and cognitive decline. It has been shown that the presence of modifiable risk factors exacerbates endothelial dysfunction. This study primarily aimed to identify which among various perfusion MRI methodologies could be effectively utilized to non-invasively identify early pathological alterations as a result of endothelial dysfunction. We compared these perfusion MRI measurements to invasive immunohistochemistry to detect early pathological alterations in the cerebral vasculature of a rat model of multiple cardiovascular co-morbidities (the ZSF1 Obese rat) at several stages of the cerebrovascular pathology. We observed cerebral hyperperfusion, expressed by increased Cerebral Blood Flow (CBF) and increased BBB permeability in the ZSF1 Obese rats, at an early stage of disease development. The increase in CBF observed with Arterial Spin Labeling (ASL) was lost during later stages of disease progression. These findings are in line with recent clinical findings in early stages of Alzheimer's disease (AD), that also show early increases in CBF.
Competing Interests: Declaration of competing interest Elizabeth A.V. Jones reports financial support was provided by Horizon Europe. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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