High concentration hydrogen attenuates sepsis-induced acute kidney injury by promoting mitochondrial biogenesis and fusion.

Autor: Pei S; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China., Zheng L; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Shanxi Provincial People's Hospital, Tai Yuan, Shanxi, China., Tian Z; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Huanghua Development Zone Boai Hospital, Affiliate of Oriental College of Beijing University of Traditional Chinese Medicine, Huanghua, Hebei, China., Meng S; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China., Wang Z; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China., Fan Y; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China., Liu J; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China., Cui Y; Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Electronic address: cuiyanbio45@163.com., Xie K; Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: mzk2011@126.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Dec 25; Vol. 143 (Pt 2), pp. 113410. Date of Electronic Publication: 2024 Oct 20.
DOI: 10.1016/j.intimp.2024.113410
Abstrakt: Sepsis is a major cause of mortality among critical patients. Acute kidney injury (AKI) is the common complication in patients with sepsis, characterized by rapid deterioration of renal function. The purpose of this study is to assess the impact of inhaling high concentration hydrogen on septic mice with AKI and to examine the involvement of mitochondria in this process. High concentration hydrogen does not cause hypoxia and can alleviate AKI and improve 7-day survival in septic mice. Inflammatory factors are markedly elevated in the serum and renal tissues in CLP group which are dramatically down-regulated by hydrogen. The activities of both antioxidant enzymes are significantly reduced after CLP, whereas hydrogen markedly increases the activities of SOD and CAT. MMP is found to be significantly lower in CLP group whereas this effect is reversed by hydrogen. The trend of ATP content in renal tissues corresponded with that of MMP. There is a substantial downregulation of PGC-1α, Nrf2, and TFAM protein in CLP group. Drp1 expression is significantly higher in CLP group compared to Sham group, while the opposite trend is observed for MFN2. Hydrogen can reverse these changes. Inhalation of high concentration hydrogen can improve acute kidney injury, 7-day survival, inflammatory response and oxidative stress in septic mice. The mechanism may be related to inhibit renal mitochondrial fission and promote mitochondrial fusion and biogenesis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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