The antimicrobial resistance profile in poultry of Central and Southern India is evolving with distinct features.

Autor: Aseem A; Drug Safety Division, ICMR-National Institute of Nutrition, Hyderabad 500007, India., Sagar P; Drug Safety Division, ICMR-National Institute of Nutrition, Hyderabad 500007, India., Reddy NS; Drug Safety Division, ICMR-National Institute of Nutrition, Hyderabad 500007, India., Veleri S; Drug Safety Division, ICMR-National Institute of Nutrition, Hyderabad 500007, India. Electronic address: shobi.veleri@icmr.gov.in.
Jazyk: angličtina
Zdroj: Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2024 Nov; Vol. 114, pp. 102255. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1016/j.cimid.2024.102255
Abstrakt: Antimicrobial resistance (AMR) is fast emerging and is depleting antibiotics repertoire. Poultry is a major source for AMR because focus to enhance its production by modern practices widely uses antibiotics. India and China are major producers of meat and have hotspots of AMR. The Central and Southern India were predicted as emerging hotspots for AMR in poultry but no data available to substantiate it. To this end, we collected chicken feces from poultry farms in these regions and isolated genomic DNA. Further, shotgun whole genome sequencing was performed for metagenomics analysis. For the first time, we report the AMR gene profiles in poultry from Kerala and Telangana. The samples exhibited a higher prevalence of gram-negative and anaerobic species. The high priority pathogens in India were detected, like E.coli, Clostridium perfringens, Klebsiella pneumonia Staphylococcus aureus, Enterococcous faecalis, Pseudomonas aeruginosa, Bacteriodes fragiles. Conspicuously, the Southern India had the highest abundance of AMR genes than the Central India. E.coli was significantly more prevalent in the southernmost zone of India than in other sites. Our data had many common AMR profile features of the European Union (EU) poultry farms but lacked mcr-1, which was a lately emerged AMR gene in E.coli. Our data revealed the extent of AMR gene evolved in the Central and Southern India. It is comparable to the EU data but severity is lesser than in the EU.
Competing Interests: Declaration of Competing Interest The authors have no competing interests to declare.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: