Hypothalamus Connectivity in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Autor: Byrne H; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Knight SJ; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.; School of Psychological Sciences, The University of Melbourne, Melbourne, Australia., Josev EK; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Scheinberg A; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Beare R; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; National Centre for Healthy Ageing and Peninsula Clinical School, Monash University, Melbourne, Australia., Yang JYM; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.; Department of Neurosurgery, Neuroscience Advanced Clinical Imaging Service (NACIS), The Royal Children's Hospital, Melbourne, Australia.; Neuroscience Research, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia., Oldham S; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia., Rowe K; Department of General Medicine, Royal Children's Hospital, Melbourne, Australia., Seal ML; Developmental Imaging, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2024 Oct; Vol. 102 (10), pp. e25392.
DOI: 10.1002/jnr.25392
Abstrakt: Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling illness of unknown etiology. Increasing evidence suggests hypothalamic involvement in ME/CFS pathophysiology, which has rarely been explored using magnetic resonance imaging (MRI) in the condition. This work aimed to use MRI to examine hypothalamus connectivity in adolescents with ME/CFS and explore how this relates to fatigue severity and illness duration. 25 adolescents with ME/CFS and 23 healthy controls completed a neuroimaging protocol consisting of structural and multishell diffusion-weighted imaging sequences, in addition to the PedsQL Multidimensional Fatigue Scale to assess fatigue severity. Information about illness duration was acquired at diagnosis. Preprocessing and streamlines tractography was performed using QSIPrep combined with a custom parcellation scheme to create structural networks. The number (degree) and weight (strength) of connections between lateralized hypothalamus regions and cortical and subcortical nodes were extracted, and relationships between connectivity measures, fatigue severity, and illness duration were performed using Bayesian regression models. We observed weak-to-moderate evidence of increased degree, but not strength, of connections from the bilateral anterior-inferior (left: pd [%] = 99.18, median [95% CI] = -22.68[-40.96 to 4.45]; right: pd [%] = 99.86, median [95% CI] = -23.35[-38.47 to 8.20]), left anterior-superior (pd [%] = 99.33, median [95% CI] = -18.83[-33.45 to 4.07]) and total left hypothalamus (pd [%] = 99.44, median [95% CI] = -47.18[-83.74 to 11.03]) in the ME/CFS group compared with controls. Conversely, bilateral posterior hypothalamus degree decreased with increasing ME/CFS illness duration (left: pd [%] = 98.13, median [95% CI]: -0.47[-0.89 to 0.03]; right: pd [%] = 98.50, median [95% CI]:-0.43[-0.82 to 0.05]). Finally, a weak relationship between right intermediate hypothalamus connectivity strength and fatigue severity was identified in the ME/CFS group (pd [%] = 99.35, median [95% CI] = -0.28[-0.51 to 0.06]), which was absent in controls. These findings suggest changes in hypothalamus connectivity may occur in adolescents with ME/CFS, warranting further investigation.
(© 2024 The Author(s). Journal of Neuroscience Research published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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