Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice.

Autor:	Garcia-Flores V; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO., Liu Z; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI., Romero R; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI.; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI., Pique-Regi R; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI., Xu Y; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO., Miller D; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO., Levenson D; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI., Galaz J; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Winters AD; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI., Farias-Jofre M; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Panzer JJ; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI., Theis KR; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI., Gomez-Lopez N; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI and Bethesda, MD.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Dec 01; Vol. 213 (11), pp. 1620-1634.
DOI:	10.4049/jimmunol.2400467
Abstrakt:	Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammation, for which there is no established treatment. In this study, we propose homeostatic macrophages to prevent PTB and adverse neonatal outcomes caused by in utero sterile inflammation. Single-cell atlases of the maternal-fetal interface revealed that homeostatic maternal macrophages are reduced with human labor. M2 macrophage treatment prevented PTB and reduced adverse neonatal outcomes in mice with in utero sterile inflammation. Specifically, M2 macrophages halted premature labor by suppressing inflammatory responses in the amniotic cavity, including inflammasome activation, and mitigated placental and offspring lung inflammation. Moreover, M2 macrophages boosted gut inflammation in neonates and improved their ability to fight systemic bacterial infections. Our findings show that M2 macrophages are a promising strategy to mitigate PTB and improve neonatal outcomes resulting from in utero sterile inflammation. (Copyright © 2024 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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