Evaluation of Risk Factors Associated with Recurrence and Death in Patients with Thyroid Cancer From 2008 to 2023 in the West of Iran.

Autor:	Khazaei S; Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran., Abdollahi Yeganeh S; Neurosurgery Research Group, Student Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Salim Bahrami SAR; Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Borzouei S; Department of Endocrinology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Jazyk:	angličtina
Zdroj:	Journal of research in health sciences [J Res Health Sci] 2024 Sep 30; Vol. 24 (4), pp. e00632. Date of Electronic Publication: 2024 Aug 01.
DOI:	10.34172/jrhs.2024.167
Abstrakt:	Background: Thyroid carcinoma (TC) is a global clinical concern, and its incidence has progressively increased worldwide. Early detection of TC and subsequently decreased age at the diagnosis seem to result from extensive employment of imaging modalities, biopsy techniques, and improvements in the healthcare system. Study Design: A retrospective cohort study. Methods: Overall, 400 patients diagnosed with TC following thyroidectomy in the Endocrinology Clinic, who were followed for fifteen years, were investigated in this study. The checklist included patients' demographic characteristics, clinical information, and response to treatment, recurrence, and death. Results: There were 19.25% men and 80.75% women. The mean age was 41.005±15.58 years. The risk of death and recurrence was significantly higher in men, patients>65 years, smokers, patients with a family history of TC, undifferentiated cancer, multifocality, and stages III and IV ( P <0.001). Each additional year of life was associated with a 21% increase in the risk of death ( P <0.001). Smoking was associated with a 4.36-fold increase in the risk of death ( P =0.05). For each additional year of life, the probability of recurrence increased by 3% ( P =0.009). Men were 4.73 times more likely to recur ( P <0.001) than women. Conclusion: To employ the proper therapeutic intervention and perform meticulous postoperative surveillance, it is crucial to consider the predictive influence of pertinent elements. Diagnosing TC in its early stages is essential for the healthcare system because of the increased incidence, younger age at diagnosis, and overall favorable prognosis of TC. (© 2024 The Author(s); Published by Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
Databáze:	MEDLINE
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