Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats.

Autor:	Askari R; Department of Exercise Physiology, Faculty of Sport Science, Hakim Sabzevari University, Sabzevar, Iran., NasrAbadi M; Department of Exercise Physiology, Faculty of Sport Science, Hakim Sabzevari University, Sabzevar, Iran., Haghighi AH; Department of Exercise Physiology, Faculty of Sport Science, Hakim Sabzevari University, Sabzevar, Iran., Mahin MJ; Department of Exercise Physiology, Faculty of Sport Science, Hakim Sabzevari University, Sabzevar, Iran., Somayeh R; Department of Exercise Physiology, Faculty of Human Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran., Pusceddu M; The Sports Physiology Laboratory, University of Cagliari, Italy.
Jazyk:	angličtina
Zdroj:	AIMS neuroscience [AIMS Neurosci] 2024 Aug 21; Vol. 11 (3), pp. 260-274. Date of Electronic Publication: 2024 Aug 21 (Print Publication: 2024).
DOI:	10.3934/Neuroscience.2024017
Abstrakt:	Purpose: The cyclic AMP response element-binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity. The study investigates how combined water-based training affects hippocampal neuron plasticity and memory function in old rats. Methods: 16 Wistar male rats 24-month-old were randomly divided into two groups: combined training (n = 8) and control (n = 8). Four sessions were performed per week for 10 weeks, and consisted of resistance and endurance training in water. The control group was placed in a water container during training for 30 minutes to be homogenized in terms of the stress conditions. The.NGF and CREB genes in the hippocampus were evaluated and the working memory was measured using real-time PCR and Y-maze tests. The SPSS 26 software was utilized in which independent t-tests were used to analyze the genes and the Mann-Whitney U test was used to analyze functional memory with a significant level of (P < 0.05). Results: The combined training resulted in a significant rise in NGF and CREB gene expression in the hippocampus tissue of elderly rats compared to the control group (P < 0.05); however, there was no notable difference in the Y maze performance test between the two groups (P < 0.05). Conclusions: These findings suggest that water-based combined training has beneficial effects on gene expression of NGF and CREB; however, it is necessary to conduct more studies to comprehend the effects of combined training on memory function. Competing Interests: Conflict of interest: The authors declare that there are no conflicts of interest in this research. (© 2024 the Author(s), licensee AIMS Press.)
Databáze:	MEDLINE
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