Olmsted Syndrome in a 12-year-old Filipino Male: A Case Report and Future Directions.
| Autor: | Pandapatan AT; Department of Dermatology, Philippine General Hospital, University of the Philippines Manila., Tan CJ; Department of Dermatology, Philippine General Hospital, University of the Philippines Manila., Tan JAS; Department of Dermatology, Philippine General Hospital, University of the Philippines Manila. |
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| Jazyk: | angličtina |
| Zdroj: | Acta medica Philippina [Acta Med Philipp] 2024 Sep 30; Vol. 58 (17), pp. 83-87. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024). |
| DOI: | 10.47895/amp.v58i17.7957 |
| Abstrakt: | We report a case of a Filipino child who presented with yellowish hyperkeratotic plaques on the palms and soles with palmar transgredient extension to the wrists, a yellowish hyperkeratotic plaque over the coccygeal area, and brownish-black hyperkeratotic perianal plaques. Patient had delayed physical development and short stature, but no intellectual disability. Histopathologic examination showed palmoplantar keratoderma. These clinical findings of symmetrical palmoplantar keratoderma with periorificial keratotic plaques were consistent with Olmsted Syndrome. Oral retinoids with topical keratolytics afforded significant improvement with increased hand mobility. Although there is no curative management for these patients, current experimental therapies like epidermal growth factor receptor (EGFR) inhibitors and Transient Receptor Potential Vanilloid-3 (TRPV3) antagonists are promising. Olmsted Syndrome is a rare genodermatosis with 73 cases officially reported as of this writing. This is the first case to be reported from the Philippines. Competing Interests: All authors declared no conflicts of interest. (© 2024 Acta Medica Philippina.) |
| Databáze: | MEDLINE |
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