Disparities in structural brain imaging in older adults from rural communities in Southern Nevada.

Autor:	Zhuang X; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.; Interdisciplinary Neuroscience PhD Program, University of Nevada, Las Vegas, Las Vegas, NV, United States., Cordes D; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.; Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, United States., Caldwell JZK; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States., Bender AR; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States., Miller JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2024 Oct 04; Vol. 16, pp. 1465744. Date of Electronic Publication: 2024 Oct 04 (Print Publication: 2024).
DOI:	10.3389/fnagi.2024.1465744
Abstrakt:	Introduction: Identifying the associations between rural-living or neighborhood disadvantage and neurobiology may clarify rural-urban disparities in older adults with cognitive impairment related to Alzheimer's disease. Methods: We examined rural-urban differences and neighborhood disadvantages in brain cortical thickness (CT) measures among 71 rural and 87 urban-dwelling older adults. Analysis of covariance was used to test each FreeSurfer-derived CT measures' associations with rural-urban living, clinical impairment status, and their interactions. Post-hoc linear regressions were used to test the association between CT measures and neighborhood disadvantage index. Results: Rural-dwelling older adults had thinner cortices in temporal and inferior frontal regions compared to urban participants, especially among clinically normal participants, where the thinner temporal cortex further correlated with higher neighborhood disadvantage. Conversely, rural participants had thicker cortices in superior frontal, parietal and occipital regions. Discussion: Our results suggest a complex interplay between community contexts and neurobiology. For memory-related regions, rural-living and neighborhood disadvantage might be negatively associated with subjects' brain structures. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Zhuang, Cordes, Caldwell, Bender and Miller.)
Databáze:	MEDLINE
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