David Julius and Ardem Patapoutian: Pioneers in Sensory Biology and Neuroscience.
| Autor: | Rukadikar C; Physiology, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND., Charulata K; Physiology, Symbiosis Medical College for Women (SMCW), Pune, IND., Dipankar SP; Physiology, All India Institute of Medical Sciences, Mangalagiri, Mangalagiri, IND., Nisargandha MA; Physiology, Sundarlal Patwa Government Medical College, Mandsaur, Mandsaur, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Sep 20; Vol. 16 (9), pp. e69779. Date of Electronic Publication: 2024 Sep 20 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.69779 |
| Abstrakt: | Sensory biology is a critical area within neuroscience, exploring how organisms respond to environmental stimuli such as temperature, pain, and mechanical forces. David Julius and Ardem Patapoutian have made landmark contributions to this field by identifying crucial receptors. Julius's discovery of transient receptor potential (TRP) channels, including transient receptor potential cation channel subfamily V member 1 (TRPV1), which detects heat and pain, revolutionized sensory biology and opened new paths for pain management. Similarly, Patapoutian's identification of Piezo channels, which respond to mechanical stimuli like touch and pressure, has deepened our understanding of sensory perception. Their combined work has not only advanced scientific knowledge but also introduced potential treatments for chronic pain and sensory disorders. This paper reviews their contributions and the broader implications for sensory biology and therapeutic developments. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Rukadikar et al.) |
| Databáze: | MEDLINE |
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