Use of Onyx Frontier ™ for intracranial stenting in stroke patients: A multicenter retrospective study.

Autor:	Chahine A; Department of Neurology, University of Chicago, Chicago, IL, USA., Morsi RZ; Department of Neurology, University of Chicago, Chicago, IL, USA., Thind S; Department of Neurology, University of Chicago, Chicago, IL, USA., Kass-Hout O; Department of Neurology, Access TeleCare, Dallas, TX, USA., Becske T; Department of Neurology, UNC REX Healthcare, Raleigh, NC, USA., Khaldi A; Department of Neurosurgery, WellStar Health System, Marietta, GA, USA., Karar L; Department of Neurology, University of Chicago, Chicago, IL, USA., Baskaran A; Department of Neurology, University of Chicago, Chicago, IL, USA., Carrión-Penagos J; Department of Neurology, University of Chicago, Chicago, IL, USA., Desai H; Department of Neurology, University of Chicago, Chicago, IL, USA., Kothari SA; Department of Neurology, University of Chicago, Chicago, IL, USA., Rana R; Department of Neurology, University of Chicago, Chicago, IL, USA., Verhagen Metman O; Department of Neurology, University of Chicago, Chicago, IL, USA., Zakaria J; Department of Neurology, University of Chicago, Chicago, IL, USA., Shah AP; Department of Neurology, University of Chicago, Chicago, IL, USA., Paul JD; Department of Neurology, University of Chicago, Chicago, IL, USA., Nathan S; Department of Neurology, University of Chicago, Chicago, IL, USA., Siegler JE; Department of Neurology, University of Chicago, Chicago, IL, USA., Mendelson SJ; Department of Neurology, Access TeleCare, Dallas, TX, USA., Mansour A; Department of Neurology, University of Chicago, Chicago, IL, USA., Hurley MC; Department of Radiology, University of Chicago, Chicago, IL, USA., Prabhakaran S; Department of Neurology, University of Chicago, Chicago, IL, USA., Gupta R; Department of Radiology, University of Chicago, Chicago, IL, USA., Kass-Hout T; Department of Neurology, University of Chicago, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences [Interv Neuroradiol] 2024 Oct 21, pp. 15910199241286922. Date of Electronic Publication: 2024 Oct 21.
DOI:	10.1177/15910199241286922
Abstrakt:	Background: Acute ischemic stroke (AIS) due to intracranial atherosclerotic disease (ICAD) carries a high risk of recurrence despite aggressive medical management. The aim of our study is to present our initial experience with the Onyx Frontier™ balloon-mounted drug-eluting stent (Medtronic, Santa Rosa, CA) for AIS due to ICAD. Methods: We conducted a multicenter retrospective cohort study describing the technical feasibility, safety, and performance of using the Onyx Frontier™ balloon-mounted drug-eluting stent in patients with acute intracranial vessel occlusion due to ICAD across three comprehensive stroke centers in the United States. Results: We included 23 patients in our study (mean age 67.3 [10.7]; females: n = 13/23, 56.5%). Most patients were Black (n = 14/23, 60.9%). The most common site of vessel occlusion was the M1 branch of the middle cerebral artery (MCA) (n = 14/23, 60.9%), followed by the vertebrobasilar system (n = 5/23, 21.7%), and the internal carotid artery (n = 3/23, 13.0%). Treatment with the Onyx Frontier™ stent was associated with a final mTICI score ≥2b for 100% of patients, with no vessel perforations or distal embolization. None of the patients had any restenosis or re-treatment over a median follow-up of 3.5 months (interquartile range [IQR] 7.8). All cases required a single stent except for one, where two were deployed. Transfemoral access was used in most cases (n = 18/23, 78.3%), with one in-hospital death due to access site complication (n = 1/23, 4.3%). Conclusions: This is the largest multicenter cohort study demonstrating the feasibility and safety of using the Onyx Frontier™ balloon-mounted zotarolimus-eluting stent to treat symptomatic AIS due to ICAD. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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