Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.

Autor: Andrews SJ; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA., Boeriu AI; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St.Louis, Missouri, USA.; Department of Neurology, Washington University School of Medicine, St.Louis, Missouri, USA., Renton AE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Fulton-Howard B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Brenowitz WD; Kaiser Permanente Center for Health Research, Portland, Oregon, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA., Yaffe K; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.; Department of Neurology, University of California San Francisco, San Francisco, California, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Dec; Vol. 20 (12), pp. 8595-8604. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1002/alz.14300
Abstrakt: Introduction: Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities.
Methods: We analyzed the association of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) and modified CAIDE (mCAIDE) scores with dementia risk using logistic regression models stratified by race/ethnicity in National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Neuroimaging Initiative (ADNI), and assessed their interaction with apolipoprotein E (APOE).
Results: Higher CAIDE scores were associated with an increased risk of dementia in Asian, Latinx, and NLW participants but not in Black participants. In contrast, higher mCAIDE scores were also associated with an increased risk of dementia in Black participants. Unfavorable mCAIDE risk profiles exacerbated the apolipoprotein E*ε4 (APOE*ε4) risk effect and attenuated the APOE*ε2 protective effect.
Discussion: Our findings underscore the importance of evaluating the validity of dementia risk scores in diverse populations for their use in personalized medicine approaches to promote brain health.
Highlights: Dementia risk scores demonstrate race/ethnic-specific effects on dementia risk. Unfavorable modifiable risk profiles moderate the effect of APOE on dementia risk. Dementia risk scores need to be validated in diverse populations.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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