Alzheimer's Disease Protein Targets: Comprehensive Review and Future Directions.

Autor:	Kumar BS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India., Dinesh BGH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India., Shajan SRO; Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India., Sadashivappa NM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India., Ammunje DN; Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India., Kunjiappan S; Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamil Nadu, India., Theivendren P; Department of Pharmaceutical Chemistry, Swamy Vivekananda College of Pharmacy, Elayampalayam, Namakkal, Tamilnadu 637205, India., Pavadai P; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore 560054, Karnataka, India.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI:	10.2174/0113816128334916241006195142
Abstrakt:	Alzheimer's disease (AD) is a gradual degenerative ailment of the nervous system that is marked by the buildup of amyloid-β plaques and neurofibrillary tangles. This accumulation causes problems with the connections between nerve cells and the loss of these cells. This review paper explores the complex pathophysiology of AD, analyzing the neuronal loss reported in key brain regions like the entorhinal cortex, amygdala, hippocampus, and cortical association areas. The text also examines subcortical nuclei participation, such as the noradrenergic locus coeruleus, serotonergic dorsal raphe, and cholinergic basal nucleus. Also, this review discusses the importance of tau protein hyperphosphorylation, oxidative stress, and metal ion dysregulation in the evolution of AD. Moreover, it explores the cholinergic theory and the influence of the APOE (apolipoprotein E) genotype on the effectiveness of therapy. This article thoroughly summarizes the current knowledge on AD, including its clinical symptoms and possible treatment approaches, by combining several theories and new targets. The study highlights the connection between the degree of tangle development and the severity of dementia, underlining the need for creative methods to tackle the complex difficulties of discovering drugs for AD. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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