Immunoregulation and male reproductive function: Impacts and mechanistic insights into inflammation.

Autor: Ma Y; The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Yu X; School of PharmacyJinan, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Liu YF; School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Song B; School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Sun Z; Reproductive and Genetic Center of Integrative Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Zhao S; The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.; Affiliated Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China.; Department of Urology, Binzhou Medical University Hospital, Yantai, Shandong, China.; Institute of Urology, Shandong University, Jinan, Shandong, China.
Jazyk: angličtina
Zdroj: Andrology [Andrology] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1111/andr.13772
Abstrakt: This paper investigates the complex relationship between the immune system and male reproductive processes, emphasizing how chronic inflammation can adversely affect male reproductive health. The immune system plays a dual role; it protects and regulates reproductive organs and spermatogenesis while maintaining reproductive health through immune privilege in the testes and the activities of various immune cells and cytokines. However, when chronic inflammation persists or intensifies, it can disrupt this balance, leading to immune attacks on reproductive tissues and resulting in infertility.This study provides a detailed analysis of how chronic inflammation can impair sperm production, sperm quality, and the secretion of gonadal hormones both directly and indirectly. It also delves into the critical roles of testicular immune privilege, various immune cells, and cytokines in sustaining reproductive health and examines the impacts of infections, autoimmune diseases, and environmental factors on male fertility.
(© 2024 American Society of Andrology and European Academy of Andrology.)
Databáze: MEDLINE
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