Oral administration of ruxolitinib in psoriasis vulgaris: A case report of plaque psoriasis accompanied by myelofibrosis secondary to polisitemia vera successfully treated with oral ruxolitinib.

Autor: Çetinarslan T; Department of Dermatology and Venereology, Manisa Celal Bayar University, Manisa, Turkey., Aydoğdu İ; Department of Hematology, Manisa Celal Bayar University, Manisa, Turkey., Ermertcan AT; Department of Dermatology and Venereology, Manisa Celal Bayar University, Manisa, Turkey.
Jazyk: angličtina
Zdroj: The Journal of dermatology [J Dermatol] 2024 Oct 20. Date of Electronic Publication: 2024 Oct 20.
DOI: 10.1111/1346-8138.17510
Abstrakt: Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and immune cell infiltration. Various therapies have been discovered for psoriasis, including topical treatments, phototherapy, conventional systemic agents such as methotrexate, retinoids and ciclosporine, as well as biologics. Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors targeting Tumor Necrosis Factor alpha (TNF-α), interleukin (IL)-23 and IL-17 can be effective in psoriasis. Ruxolitinib is a US Food and Drug Administration-approved first-generation Janus kinase inhibitor for polycythemia vera, myelofibrosis, and acute graft-versus-host disease. Ruxolitinib cream has been investigated in various dermatologic diseases, including atopic dermatitis, vitiligo, psoriasis, and alopecia areata. However, there is limited data on the efficacy of oral ruxolitinib in patients with psoriasis vulgaris. Here, we report a patient diagnosed with myelofibrosis coexisting with psoriasis vulgaris, successfully treated with oral ruxolitinib.
(© 2024 Japanese Dermatological Association.)
Databáze: MEDLINE
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