Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease.

Autor:	Hård Af Segerstad EM; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway; Unit for Celiac and Diabetes Research, Clinical Sciences, Lund University, Malmoe, Sweden. Electronic address: elin.malmberg_hard_af_segerstad@med.lu.se., Borge TC; Cluster for Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway., Guo A; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Mårild K; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden., Stene LC; Cluster for Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway., Brantsæter AL; Department of Food Safety, Center for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway., Størdal K; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway; Faculty of Clinical Medicine, University of Oslo, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI:	10.1016/j.tjnut.2024.10.033
Abstrakt:	Background: High gluten and low dietary fiber in pregnancy intake is associated with an increased risk of celiac disease (CeD) in the child. Early life higher dietary quality is suggested to reduce the subsequent risk of CeD. Objectives: The aim was to investigate associations of pregnancy dietary quality and diversity with child risk of CeD. Methods: In The Norwegian Mother, Father and Child Cohort Study, 85,122 mother-child pairs had available data from a validated pregnancy food frequency questionnaire. Pregnancy dietary quality and diversity were estimated by a Pregnancy Healthy Eating Index [mean 99.3, standard deviation (SD) 9.9, range 48.8-128.3], and a Diet Diversity Score (mean 7.0, SD 1.0, range 1.6-9.8), respectively. Child CeD was captured by ≥2 diagnostic codes in the Norwegian Patient Registry. Logistic regression was used to estimate associations between pregnancy dietary quality, diversity and child CeD, adjusted for socioeconomic factors, and parents CeD [adjusted odds ratio (aOR), 95% confidence intervals (CI)]. CeD-susceptible human leukocyte antigen haplotypes (DQ2/DQ8) were present in 30,718 (45.5%). Results: Up to mean age 16.0 (SD 1.8, 12.4-19.8) y, 1363 (1.6%) children were diagnosed with CeD. Lower as well as higher pregnancy dietary quality associated with a reduced risk of CeD in the child (<5th percentile aOR = 0.67, 95% CI: 0.48, 0.93, >95th percentile aOR = 0.71, 95% CI: 0.52, 0.98, respectively, nonlinear squared term P = 0.011). Analyses on genetically susceptible children, adjustments for pregnancy iron supplementation, gluten, and dietary fiber intake, and child early life dietary quality, gluten intake and iron supplementation, supported the finding. Pregnancy dietary diversity was not associated with child CeD (aOR = 1.00, 95% CI: 0.94, 1.07/score). Conclusions: In this population-based study, lower as well as higher pregnancy dietary quality associated with a reduced risk of CeD diagnosis in the child. In contrast, no such association was observed with maternal dietary diversity. Competing Interests: Conflict of interest The authors have no conflicts of interest relevant to this article to disclose. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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