Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques.

Autor: Costin IC; West University of Timisoara, Faculty of Physics, Timisoara 300223, Romania; Clinical Emergency County Hospital Bihor, Oradea 410169, Romania., Cinezan C; Clinical Emergency County Hospital Bihor, Oradea 410169, Romania; Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410087, Romania., Marcu LG; Faculty of Informatics & Science, University of Oradea, Oradea 410087, Romania; UniSA Allied Health and Human Performance, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: loredana@marcunet.com.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Dec; Vol. 204, pp. 104538. Date of Electronic Publication: 2024 Oct 19.
DOI: 10.1016/j.critrevonc.2024.104538
Abstrakt: Cardio-oncology is lately gaining more attention due to radiation-induced cardiac events reported by a very large number of studies. In view of this, the current overview of the literature aimed to encompass all studies from the past 15 years to assess changes in cardiac dose due to treatment evolution, as well as the changes in treatment planning customs to incorporate not only the heart as a whole but also cardiac substructures. Modern treatment techniques, particularly proton therapy, offers superior cardiac sparing compared to more established radiotherapy, for all evaluated tumor sites. Intensity modulation, particularly coupled with respiratory gating shows significant improvement in dose-volume parameters pertaining to the heart. While past studies considered mean heart dose as the only reference for cardiac toxicities, recommendations for the other cardiac substructures to be dosimetrically assessed during planning are becoming more common.
Competing Interests: Declaration of Competing Interest No conflict of interest needs to be declared.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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