Optimal timing for video assisted thoracic surgery decortication for improved survival in chronic empyema.

Autor: Lin CM; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan., Chen YL; Surgery Clinical Research Center, Changhua Christian Hospital, Changhua City, Taiwan., Cheng YF; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan., Cheng CY; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan., Huang CL; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan., Hung WH; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan., Wang BY; Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua City, Taiwan. 156283@cch.org.tw.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. 156283@cch.org.tw.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 19; Vol. 14 (1), pp. 24548. Date of Electronic Publication: 2024 Oct 19.
DOI: 10.1038/s41598-024-75569-w
Abstrakt: Background: Video-assisted thoracic surgery decortication for phase 3 thoracic empyema is widely accepted, but its optimal timing has not been established. We aim to investigate and assess this timing, in terms of overall survival, for chronic empyema.
Methods: Two hundred four patients with pneumonia-caused phase 3 empyema were treated with video-assisted thoracic surgery decortication over 10-years at Changhua Christian Hospital. The 90-day post-operative survival status was analyzed, and we compared the survivor group versus the non-survivor group. A receiver operating characteristic curve was used to identify the optimal decortication timing.
Results: A comparison between survivors and non-survivors showed statistical differences among age (p=0.004), presence of cardiovascular disease (p=0.018), presence of end-stage renal disease (p=0.002), duration to surgery (p=0.013), length of intensive care unit stay (p=0.010), and overall length of hospital stay (p=0.015). ROC curve analysis determined the cut-off for video-assisted thoracic surgery decortication, based on optimal 90-day post-operative survival, to be 7.5 days after hospitalization; mortality increases threefold thereafter (14.2% vs 44.6%, p<0.001). Multivariate analysis revealed that age, end-stage renal disease, pleural effusion pH≦7.2 and duration to surgery >7.5 days negatively impacted 90-day post-operative survival.
Conclusions: Patients receiving decortication surgery within 7.5 days of hospital admission had better overall survival.
(© 2024. The Author(s).)
Databáze: MEDLINE
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