The surface-based degree centrality of patients with lifelong premature ejaculation: A resting-state fMRI study.

Autor: Zhou F; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China., Wu W; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China., He X; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China., Cao L; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China., Ni L; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: niling_2008@163.com., Lu J; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: b101230039@gmail.com.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2024 Nov 22; Vol. 561, pp. 87-91. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1016/j.neuroscience.2024.10.026
Abstrakt: The aim of this study was to investigate alterations in the resting-state brain functional network characteristics of lifelong premature ejaculation (PE) patients using surface-based degree centrality (DC), and to analyze the correlation between these alterations and clinical symptoms in PE patients. The study included individuals with lifelong PE (patient group, n = 36) and a control group matched by age and education level (control group, n = 22). Resting-state functional magnetic resonance imaging (fMRI) scans were performed on all participants. Surface-based degree centrality analysis was conducted and the differences between the two groups were compared using t-tests. Further, the DC values of brain regions showing significant differences were correlated with clinical symptoms. Compared to the control group, the patient group exhibited significantly reduced degree centrality (DC) values in the left precuneus and significantly increased DC values in the right supplementary motor area (SMA). Furthermore, intravaginal ejaculatory latency time (IELT) and Chinese Index of Premature Ejaculation (CIPE) values were positively correlated with left precuneus DC values and negatively correlated with right SMA DC values. Patients with primary lifelong ejaculation demonstrate abnormalities in key brain network nodes and their connections with relevant brain regions, which are strongly associate with clinical symptoms. These findings enhance our understanding of the neuronal pathological changes in PE patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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