Purified CD34+ Cells Transplantation in Patients with Angiitis-Induced Chronic Limb-Threatening Ischemia: A Single-Center Retrospective Study over a 10-Year Period.

Autor:	Liu H; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Jiang X; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Zou L; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Fang Y; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Fang G; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Liu Y; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Chen B; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Gu S; Departments of Hematology of Zhongshan Hospital, Fudan University, Shanghai, China., Wei Z; Departments of Hematology of Zhongshan Hospital, Fudan University, Shanghai, China., Liu P; Departments of Hematology of Zhongshan Hospital, Fudan University, Shanghai, China., Fu W; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China., Pan T; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China. Electronic address: tianyuepan@126.com., Dong Z; Departments of Vascular Surgery of Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China. Electronic address: dzh926@126.com.
Jazyk:	angličtina
Zdroj:	Annals of vascular surgery [Ann Vasc Surg] 2025 Jan; Vol. 110 (Pt B), pp. 469-479. Date of Electronic Publication: 2024 Oct 18.
DOI:	10.1016/j.avsg.2024.09.062
Abstrakt:	Background: Angiitis-induced chronic limb-threatening ischemia (AICLTI) is defined as chronic limb-threatening ischemia caused by thromboangiitis obliterans or other arteritis-related autoimmunological diseases. In the current study, we aimed to report the 10-year outcomes of AICLTI patients who underwent purified cluster of differentiation 34 positive (CD34 + ) cells (PCCs) transplantation. Methods: AICLTI patients who underwent PCCs transplantation at our center from May 2009 to September 2011 were retrospectively enrolled. The main outcome was major amputation-free survival (MAFS); other outcomes included Rutherford classification, intolerable pain-free walking time, Wong-Baker Faces Pain Rating Scale, recurrence, new lesions, quality of life and patients' posttransplantation work conditions. Results: Twenty-four patients were enrolled with a mean age of 41.5 ± 7.8 years. Three underwent major amputation during the follow-up, and the 10-year MAFS was 87.5%. Eight were observed to have recurrence, and 2 had new lesions; the 10-year recurrence-free rate was 66.1%. All patients were unable to work at admission, 17 (70.8%) patients were reemployed after transplantation. Conclusions: The current study further demonstrated satisfactory long-term efficacy of PCCs transplantation, with a 10-year MAFS of 87.5%. However, the 10-year recurrence-free rate of 66.1% suggested that strict and regular long-term follow-up is necessary. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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