Circulation of avian Chlamydia abortus in the Netherlands and community-acquired pneumonia: an outbreak investigation and retrospective cohort study.

Autor:	Raven S; Department of Infectious Diseases, Public Health Service Region Utrecht, Zeist, Netherlands; Radboud University Medical Center, Research Institute for Medical Innovation, Department of Primary and Community Care, Nijmegen, Netherlands. Electronic address: stijn.raven@radboudumc.nl., Heijne M; Wageningen Bioveterinary Research, Wageningen University & Research, Lelystad, Netherlands., Koomen J; Wageningen Bioveterinary Research, Wageningen University & Research, Lelystad, Netherlands., Doornenbal G; Department of Infectious Diseases, Public Health Service Region Utrecht, Zeist, Netherlands., Maas M; Department of Infectious Diseases, Public Health Service Region Utrecht, Zeist, Netherlands; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Jacobs P; Netherlands Food and Consumer Product Safety Authority, Utrecht, Netherlands., Keur I; Netherlands Food and Consumer Product Safety Authority, Utrecht, Netherlands., Dijkstra F; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Reukers D; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Platenburg M; Department of Pulmonology, St Antonius Hospital, Nieuwegein, Netherlands., Verweij SP; Department of Pulmonology, St Antonius Hospital, Nieuwegein, Netherlands., Mager HJ; Department of Pulmonology, St Antonius Hospital, Nieuwegein, Netherlands., Totté J; Department of Medical Microbiology, Immunology and Infection Control, St Antonius Hospital, Nieuwegein, Netherlands; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., Vainio S; Department of Medical Microbiology, Immunology and Infection Control, St Antonius Hospital, Nieuwegein, Netherlands., Bongaerts M; Department of Medical Microbiology (and reference laboratory for human chlamydia infections from animal origin), Zuyderland Medical Center, Sittard-Geleen, Netherlands., Heddema E; Department of Medical Microbiology (and reference laboratory for human chlamydia infections from animal origin), Zuyderland Medical Center, Sittard-Geleen, Netherlands.
Jazyk:	angličtina
Zdroj:	The Lancet. Infectious diseases [Lancet Infect Dis] 2024 Oct 16. Date of Electronic Publication: 2024 Oct 16.
DOI:	10.1016/S1473-3099(24)00529-2
Abstrakt:	Background: In 2021, a novel group of Chlamydia strains in wild birds was classified as avian Chlamydia abortus, with unknown zoonotic potential. We report relevant features of avian C abortus infections from a Dutch family cluster and unrelated historical cases using clinical, epidemiological, and microbiological data. Methods: An outbreak of avian C abortus started in the Netherlands in December, 2022. Source investigation was done using questionnaires to interview patients and environmental sampling. The outbreak strain of avian C abortus was cultured from three patients from whom sufficient material was available for culture and underwent whole-genome analysis. The outbreak strains and retrospective cohort study strains previously submitted to the National Human Psittacosis surveillance programme in the Netherlands between 2010 and 2022 were typed by partial ompA sequencing. Strains with the same aberrant ompA genotype were further analysed with XerC gene plasmid analysis and compared with closely related Chlamydia sequences available in GenBank. Findings: An avian C abortus strain caused a cluster of respiratory illness in four family members. Three patients were hospitalised with community-acquired pneumonia, one of whom was admitted to the intensive care unit. The faeces of wild birds were considered a probable source for the index infection. For two family members, human-to-human transmission was a plausible route. Ten historical cases could be identified with avian C abortus with the same ompA genotype. All patients had been admitted to hospital, at least five developed pneumonia, and one died. Interpretation: This cluster supports that avian C abortus strains can cause human infections and underlines that human-to-human transmission should be considered when tracing the source of such infections. Funding: National Institute for Public Health and the Environment and Dutch Ministry of Agriculture, Fisheries, Food Security and Nature. Translation: For the Dutch translation of the abstract see Supplementary Materials section. Competing Interests: Declaration of interests We declare no competing interests. (Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.)
Databáze:	MEDLINE
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