Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study.

Autor: Tos SM; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA. Electronic address: salem.m.97@hotmail.com., Hajikarimloo B; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Mantziaris G; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Shaaban A; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Pham D; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Dayawansa S; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Wei Z; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., McKendrick LM; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Niranjan A; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Lunsford LD; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Peker S; Department of Neurological Surgery, Koc University School of Medicine, Istanbul, Turkey., Samanci Y; Department of Neurological Surgery, Koc University School of Medicine, Istanbul, Turkey., Liscak R; Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic., May J; Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic., Mathieu D; Department of Neurological Surgery, Université de Sherbrooke, Centre de recherche du CHUS, Canada., Picozzi P; Department of Neurological Surgery, IRCCS Humanitas Research Hospital, Milan, Italy., Franzini A; Department of Neurological Surgery, IRCCS Humanitas Research Hospital, Milan, Italy., Warnick RE; Gamma Knife Center, Jewish Hospital, Mayfield Clinic, Cincinnati, OH, USA., Schoenhals JE; Department of Radiation Oncology, The Ohio State University, OH, USA., Palmer JD; Department of Radiation Oncology, The Ohio State University, OH, USA., Xu Z; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., Sheehan JP; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA. Electronic address: jsheehan@virginia.edu.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 Nov; Vol. 129, pp. 110879. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1016/j.jocn.2024.110879
Abstrakt: Background: Hemangioblastomas (HBs) are rare, benign central nervous system (CNS) neoplasms that rarely occur in the supratentorial. Resection with the goal of gross total resection (GTR) is often considered the primary treatment. Stereotactic radiosurgery (SRS) has been utilized more commonly in unresectable or partially resected cases. In this study, we aimed to evaluate SRS's effectiveness and clinical outcomes in supratentorial HBs.
Methods: A retrospective analysis of multi-centers from 1993 to 2022 was conducted on patients with supratentorial HB treated with SRS.
Results: The study included 13 patients with 30 supratentorial HBs (24 von Hippel-Lindau (VHL), 6 sporadic). Median age was 26 years. Most tumors were solid (86.2 %). SRS was primary treatment in 86.7 % of cases and adjuvant in 13.3 %. VHL lesions were significantly smaller than sporadic ones (0.2 vs. 3.7 cc, p = 0.009). Median margin dose was higher in VHL cases (17 vs. 13.0 Gy, P = 0.031). For VHL cases, local control (LC) was 100 % at 6 months, 96 % (95 % CI: 88 %, 100 %) from 12 to 60 months post-SRS. For sporadic cases, LC was 100 % at 6 months, 80 % (95 % CI: 52 %, 100 %) from 12 to 60 months post-SRS (p = 0.39). No adverse radiation events or mortality occurred.
Conclusion: SRS demonstrated a promising role in the clinical course of supratentorial HBs. It can be considered an effective alternative to surgical resection and even a first-line therapeutic option in appropriately selected cases.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE