May high mobility group box protein-1 be a biomarker for major depressive disorder?

Autor: Köse AE; Department of Psychiatry, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. Electronic address: dr.aliemrekose@gmail.com., Turan T; Department of Psychiatry, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. Electronic address: tayfunturan@hotmail.com., Kilic E; Department of Biochemistry, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey. Electronic address: eserk@erciyes.edu.tr.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2024 Nov 15; Vol. 396, pp. 578466. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1016/j.jneuroim.2024.578466
Abstrakt: High Mobility Group Box Protein-1 (HMGB1), which has proinflammatory properties, is known to be involved in psychiatric disorders as far as we know, there are only one clinical studies investigating the role of HMGB1 in major depressive disorder (MDD). In this study, we aimed to investigate the role of HMGB1 in the etiopathogenesis of MDD and whether HMGB1 can be used as a biomarker in MDD by measuring the serum HMGB1 levels of depressed patients in the episode and remission periods. This study included 30 patients diagnosed with MDD in episode, 30 patients in remission and 30 healthy controls. Each group comprised 20 female and 10 male participants. In this study, serum HMGB1 levels were found to be lower in the patient group in the episode compared to the patient group in the remission period and the healthy control group. There was no significant difference between the patient group in remission and the healthy control group in terms of serum HMGB1 levels. The fact that serum HMGB1 levels were lower in the patient group in the episode compared to the patient group in the remission period and the control group may be related to the neuroprotective effects of HMGB1. HMGB1 may be used as a biomarker for MDD.
Competing Interests: Declaration of competing interest None. The financial expenses of this study were covered by the researchers.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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