Multinational epidemiological analysis of oral human papillomavirus incidence in 3,137 men.

Autor: Dube Mandishora RS; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA., Dickey BL; Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA., Fan W; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA., Sirak B; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA., Isaacs-Soriano K; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA., Rathwell J; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA., Abrahamsen M; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA., Reich RR; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA., Schell MJ; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA., Lazcano-Ponce E; Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico., Villa LL; Instituto do Cancer do Estado de São Paulo, São Paulo, Brazil.; Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Giuliano AR; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA. anna.giuliano@moffitt.org.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1038/s41564-024-01824-5
Abstrakt: Oral human papillomavirus (HPV) is associated with oropharyngeal cancer (OPC). Although OPC incidence is increasing globally, knowledge of oral HPV infection rates is limited. Here we carried out an observational epidemiological analysis of oral HPV incidence in 3,137 men enrolled from the United States, Mexico and Brazil between 2005 and 2009. Individuals were followed for new HPV infection for a median of 57 months. Cumulative incidence and factors associated with acquisition were also assessed. The incidence rate of oral oncogenic HPV was 2.4 per 1,000 person-months, did not vary with age and was constant throughout the study period. Risk of oral HPV acquisition was significantly associated with alcohol consumption, having male sexual partners, more lifetime female sexual partners, more oral sex given and higher educational attainment. These data indicate that men are at risk of acquiring oral HPV throughout their lifetime, suggesting that catch-up vaccination may reduce new infection incidence.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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